Description

6-Thioinosine 5'-Monophosphate is a chemically modified nucleotide analog of inosine monophosphate, where the oxygen atom at the 6-position is replaced by sulfur. This structural modification is critical for its role as a potent inhibitor of key enzymes in purine metabolism, making it a valuable biochemical tool and research compound. It is primarily utilized by researchers and developers in the fields of biochemistry, molecular biology, and pharmaceutical development for studying enzyme kinetics, metabolic pathways, and as a potential lead compound for therapeutic agents.

Application

• Biochemical Research: Used as a specific inhibitor of inosine monophosphate dehydrogenase (IMPDH) and other purine biosynthetic enzymes to study nucleotide metabolism and cell proliferation.
• Pharmaceutical Development: Serves as a reference standard and a key intermediate or lead compound in the research and development of immunosuppressive, antiviral, and anticancer agents.
• Enzyme Kinetics Studies: Employed in in vitro assays to determine enzyme activity, inhibition constants (Ki), and mechanism of action for drug discovery programs.
• Metabolic Pathway Analysis: A crucial tool for probing and modulating the de novo purine synthesis pathway in cellular and microbiological studies.
• Academic Research: Utilized in university and institutional labs for fundamental research into nucleotide chemistry and enzymology.

Basic Information

Product Name	6-Thioinosine 5'-Monophosphate
CAS No.	53-83-8
Molecular Formula	C10H13N4O7PS
Molecular Weight	380.27 g/mol
Synonyms	6-Thio-IMP; 6-Mercaptopurine Ribonucleotide; 6-Thioinosinic Acid; 6-Mercaptopurine Riboside 5'-Monophosphate; Thioinosine Monophosphate; TIMP; 6-Thioinosine-5'-phosphate; NSC 40774
EINECS	200-187-6

Quality Control

Every batch of 6-Thioinosine 5'-Monophosphate is manufactured and tested under strict quality management protocols. We provide comprehensive analytical data to ensure identity, purity, and consistency for research applications. A detailed Certificate of Analysis (COA) including HPLC purity, NMR identification, and other relevant specifications is supplied with each shipment to guarantee it meets your research-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, it is recommended to keep the material desiccated and under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, alkaline solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.