Description

Tetrahydrocortisol is a key metabolite of cortisol, the primary glucocorticoid hormone, and serves as a critical reference standard and biochemical intermediate. Its precise chemical structure makes it an essential tool for research and quality control in the pharmaceutical and life sciences sectors. This compound is particularly valuable for laboratories and manufacturers involved in steroid hormone analysis, metabolic pathway studies, and the development of diagnostic assays.

Application

• Pharmaceutical Reference Standard: Used for the calibration and validation of analytical methods (HPLC, GC-MS) in drug development and quality control of corticosteroid-based pharmaceuticals.
• Biochemical Research: Serves as a crucial intermediate or substrate in studies investigating cortisol metabolism, enzyme activity (e.g., 11β-hydroxysteroid dehydrogenase), and related endocrine pathways.
• Diagnostic Manufacturing: Employed in the production and standardization of diagnostic kits and reagents for measuring cortisol and its metabolites in clinical settings.
• Metabolite Analysis: Acts as a definitive standard for the identification and quantification of tetrahydrocortisol in complex biological matrices like urine or plasma for clinical research.
• Academic & Institutional Research: Utilized in universities and research institutes for fundamental studies in endocrinology, stress physiology, and steroid biochemistry.

Basic Information

Product Name	Tetrahydrocortisol
CAS No.	53-02-1
Molecular Formula	C21H34O5
Molecular Weight	366.50 g/mol
Synonyms	3α,11β,17α,21-Tetrahydroxy-5β-pregnan-20-one; 5β-Tetrahydrocortisol; Urocortisol; (3α,5β,11β)-3,11,17,21-Tetrahydroxypregnan-20-one; THF; Allotetrahydrocortisol; 5β-Pregnane-3α,11β,17α,21-tetrol-20-one; Cortisol metabolite.
EINECS	200-172-5

Quality Control

Our Tetrahydrocortisol is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive analytical and research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We support compliance with relevant pharmacopeial and research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent absorption of atmospheric moisture, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Specific Optical Rotation	Contact for details
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.