Description

Histamine Phosphate is a high-purity salt form of the biogenic amine histamine, widely recognized for its critical role in physiological and pharmacological research. This compound is essential for standardizing and calibrating analytical assays, particularly in the fields of immunology and allergy diagnostics. It serves as a fundamental reference standard and reagent for pharmaceutical R&D, clinical laboratories, and academic institutions studying inflammatory and allergic responses.

Application

• Pharmacological Research & Drug Development: Used as a key reference standard in studies of histamine receptors (H1, H2, H3, H4) for the development of antihistamines and other therapeutic agents.
• Clinical Diagnostics & Immunoassays: Essential for the calibration and quality control of diagnostic kits and ELISA tests that measure histamine levels in biological samples.
• Allergy & Immunology Studies: Employed in *in vitro* and *ex vivo* models to induce and study allergic reactions, mast cell degranulation, and anaphylaxis.
• Biochemical Reagent: Acts as a crucial substrate or standard in enzymatic assays and other biochemical research protocols.
• Pharmaceutical Quality Control: Utilized as a system suitability standard in analytical methods (e.g., HPLC) for related substance testing in pharmaceutical manufacturing.
• Academic & Teaching Laboratories: Serves as a well-characterized compound for educational demonstrations of autonomic nervous system pharmacology.

Basic Information

Product Name	Histamine Phosphate
CAS No.	51-74-1
Molecular Formula	C5H9N3 • 2H3PO4
Molecular Weight	307.14 g/mol
Synonyms	Histamine Acid Phosphate; Histamine Diphosphate; Histamine Dihydrogen Phosphate; 2-(1H-Imidazol-4-yl)ethanamine Diphosphate; 4-(2-Aminoethyl)imidazole Diphosphate; Ergamine Phosphate; 1H-Imidazole-4-ethanamine, phosphate (1:2)
EINECS	200-100-6

Quality Control

Our Histamine Phosphate is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant pharmacopeial standards (e.g., USP, EP) for reference material applications, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which can affect stability and purity.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (Titration)	Conforms
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.