Description

Guanidine Hydrochloride is a strong chaotropic agent and denaturant widely used in biochemical and pharmaceutical research. Its primary value lies in its ability to disrupt hydrogen bonding and unfold proteins, making it essential for purification and analysis. This high-purity chemical is critical for researchers and manufacturers in the biotechnology, pharmaceutical, and diagnostic industries.

Application

• Protein Denaturation & Purification: A key component in the extraction and purification of nucleic acids and proteins, particularly for RNA isolation protocols.
• Pharmaceutical Synthesis: Serves as a versatile intermediate and building block in the synthesis of various active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a strong chaotropic agent in laboratory studies of protein folding, stability, and enzyme kinetics.
• Diagnostic Reagents: Employed in the formulation of buffers and reagents for in-vitro diagnostic kits and assays.
• Cosmetic Ingredients: Acts as a precursor in the production of certain conditioning agents and surfactants for personal care products.
• Organic Synthesis: Utilized as a reagent and catalyst in various organic transformations and heterocyclic compound synthesis.

Basic Information

Product Name	Guanidine Hydrochloride
CAS No.	50-01-1
Molecular Formula	CH5N3·HCl
Molecular Weight	95.53 g/mol
Synonyms	Guanidinium Chloride; Aminoformamidine Hydrochloride; Carbamidine Hydrochloride; Guanidine Chloride; Guanidine Monohydrochloride; Iminourea Hydrochloride; Guanidine HCl
EINECS	200-002-3

Quality Control

Our Guanidine Hydrochloride is manufactured under strict quality management systems. We offer grades suitable for research and industrial applications, with a focus on consistent purity and low endotoxin levels for critical bioprocesses. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. Specifications can be tailored to meet USP, EP, or other relevant pharmacopeial standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure containers are sealed immediately after use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Assay (HPLC)	≥ 99.0%
pH (5% solution)	4.5 - 6.0
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Endotoxin (where specified)	< 0.1 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.