Description

±-Clofarabine is a synthetic purine nucleoside analog, a key intermediate in the synthesis of the active pharmaceutical ingredient Clofarabine. This compound is of critical importance for pharmaceutical research and development, particularly in the field of oncology. It is primarily utilized by pharmaceutical manufacturers and advanced research institutions engaged in the development of novel chemotherapeutic agents and nucleoside-based therapeutics.

Application

• Pharmaceutical Intermediate: Primary use as a crucial building block in the synthesis of the antineoplastic drug Clofarabine.
• Oncology Research: Serves as a reference standard and active material in preclinical studies for hematologic malignancies.
• Nucleoside Chemistry: Used in research exploring the structure-activity relationships of purine nucleoside analogs.
• Process Development: Employed in the scale-up and optimization of Clofarabine manufacturing processes within GMP environments.
• Analytical Standard: Acts as a high-purity standard for quality control and method validation (HPLC, LC-MS) in pharmaceutical analysis.

Basic Information

Product Name	±-Clofarabine
CAS No.	491594-60-6
Molecular Formula	C10H11ClFN5O3
Molecular Weight	303.68 g/mol
Synonyms	2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine (racemate); Clofarabine Racemate; (±)-2-Chloro-2'-fluoro-2'-deoxy-9-β-D-arabinofuranosyladenine; (±)-Clofarabine; 2-Chloro-2'-fluoro-2'-deoxy-9-β-D-arabinofuranosyladenine (racemic); Racemic Clofarabine; Clolar Intermediate (racemic); Clofarabine Impurity
EINECS	Contact for details

Quality Control

Our ±-Clofarabine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identification by IR and NMR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) with full traceability are provided.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.