Description

o-[2-(Fmoc-Amino)-Ethyl]-Oμ-[3-(n-Succinimidyloxy)-3-Oxopropyl]Polyethylene Glycol 3000 is a heterobifunctional polyethylene glycol (PEG) derivative engineered for advanced bioconjugation and peptide synthesis. This compound is critical for creating stable, site-specific linkages between biomolecules and surfaces or other functional groups, enhancing solubility and reducing immunogenicity. It is an essential reagent for researchers and manufacturers in pharmaceutical development, proteomics, and diagnostic assay production, where precise and reliable cross-linking is paramount.

Application

• Bioconjugation Reagent: For site-specific coupling of peptides, proteins, or antibodies to nanoparticles, surfaces, or other biomolecules.
• PEGylation Linker: Used to attach PEG chains to therapeutic peptides or proteins to improve pharmacokinetic properties, such as increased circulation half-life and reduced immunogenicity.
• Solid-Phase Peptide Synthesis (SPPS): Serves as a soluble polymer support or as a bifunctional linker for the synthesis of complex peptides, leveraging the Fmoc-protected amine for chain elongation.
• Diagnostic Probe Development: Facilitates the creation of labeled probes for immunoassays, fluorescence imaging, and other diagnostic applications by linking targeting molecules to reporter groups.
• Drug Delivery System Fabrication: A key component in constructing advanced drug delivery platforms, such as antibody-drug conjugates (ADCs) and PEGylated liposomes.
• Surface Functionalization: Used to modify materials and biosensor surfaces with bioactive molecules to create specific binding interfaces.

Basic Information

Product Name	o-[2-(Fmoc-Amino)-Ethyl]-Oμ-[3-(n-Succinimidyloxy)-3-Oxopropyl]Polyethylene Glycol 3000
CAS No.	488085-18-3
Molecular Formula	Typically CnH2n+2O(n+1) derivative (Contact for exact formula)
Molecular Weight	~3000 g/mol (Average Mn)
Synonyms	Fmoc-NH-PEG3000-NHS Ester; Fmoc-Amino-PEG3000-NHS; NHS-PEG3000-Fmoc; NHS-PEG3000-NH-Fmoc; Poly(ethylene glycol) Fmoc-amine NHS ester (MW 3000); α-Fmoc-amino-ω-NHS-PEG3000; N-Succinimidyl 3-[(2-{2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy}ethoxy)propanoate]; Heterobifunctional PEG 3000 NHS-Fmoc
EINECS	Contact for details

Quality Control

Our o-[2-(Fmoc-Amino)-Ethyl]-Oμ-[3-(n-Succinimidyloxy)-3-Oxopropyl]Polyethylene Glycol 3000 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, consistent molecular weight distribution, and functional group integrity. Certificates of Analysis (COA) are provided with each shipment, detailing specifications for assay, substitution degree, and impurity profiles. We support development under GMP and ISO 9001 guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C to -10°C under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and hydrolysis. For long-term storage, keep under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white waxy solid or powder
Identification (IR)	Conforms to structure
Average Molecular Weight (Mn)	~3000 Da (by GPC or MALDI-TOF)
Purity (HPLC)	≥ 95%
Fmoc Substitution	≥ 90%
NHS Ester Content	≥ 85%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile; partially soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.