Description

L-[2-13C]Glucose is a stable isotope-labeled analog of glucose, specifically enriched with carbon-13 at the second carbon position. This compound is essential for advanced metabolic research, enabling precise tracking and quantification of glucose utilization and metabolic flux in biological systems. It is a critical reagent for scientists and researchers in pharmaceutical development, clinical diagnostics, and nutritional studies who require high-purity, isotopically labeled substrates for mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy.

Application

• Metabolic Flux Analysis (MFA): Used as a tracer to map and quantify intracellular metabolic pathways in cell cultures, tissues, and whole organisms.
• Drug Metabolism & Pharmacokinetics (DMPK): Serves as an internal standard in LC-MS/MS and GC-MS assays for the accurate bioanalysis of glucose and related metabolites in preclinical and clinical studies.
• Clinical Research: Employed in stable isotope infusion studies to investigate glucose metabolism disorders, such as diabetes and insulin resistance, in human subjects.
• Nutritional Science: Utilized to study carbohydrate metabolism, energy expenditure, and substrate utilization in nutritional intervention studies.
• Biotechnology & Fermentation: Applied in optimizing microbial and mammalian cell culture processes by tracing carbon flow for enhanced bioproduction yields.
• Biomarker Discovery: Facilitates the identification and validation of novel metabolic biomarkers in disease states through precise isotopic labeling.

Basic Information

Product Name	L-[2-13C]Glucose
CAS No.	478519-05-0
Molecular Formula	C6H12O6 (with 13C at position 2)
Molecular Weight	181.15 g/mol (for 13C labeled form)
Synonyms	(2-13C)-L-Glucose; L-Glucose-2-13C; 2-13C-L-Glucose; L-Glucose (2-13C); [2-13C]-L-Glucose; 13C Labeled L-Glucose; Stable Isotope Labeled L-Glucose; L-(-)-Glucose-2-13C
EINECS	Contact for details

Quality Control

Our L-[2-13C]Glucose is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically >99 atom % 13C), chemical purity (by HPLC), and specific analytical data. We adhere to cGMP guidelines for the production of labeled compounds intended for research use.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR / NMR)	Conforms to structure
Isotopic Enrichment	≥ 99 atom % 13C
Chemical Purity (HPLC)	≥ 98%
Specific Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.