Description

L-α-Phosphatidylinositol-4-Phosphate (Brain, Porcine) (Ammonium Salt) is a high-purity, naturally sourced phospholipid critical for cellular signaling research. This compound serves as a key precursor and signaling molecule in the phosphoinositide pathway, which regulates vital processes like membrane trafficking, cytoskeletal organization, and cell growth. It is an essential biochemical tool for researchers in pharmaceutical discovery, lipidomics, and cell biology who require authentic, biologically relevant standards and substrates.

Application

• Biochemical Research & Standard: Used as a high-purity reference standard in lipidomics and mass spectrometry for the identification and quantification of cellular phosphoinositides.
• Enzyme Substrate: Serves as a critical native substrate for in vitro assays studying the activity of kinases (e.g., PI3K, PIP5K) and phosphatases involved in phosphoinositide metabolism.
• Liposome & Membrane Biophysics: Incorporated into artificial lipid bilayers and liposomes to study protein-lipid interactions, membrane curvature, and the biophysical properties of signaling domains.
• Cell Signaling Studies: Essential for reconstituting and investigating the PI3K/Akt and other signaling pathways in cell-free systems or for microinjection studies.
• Drug Discovery Screening: Utilized in high-throughput screening (HTS) assays to identify and characterize novel inhibitors or activators of phosphoinositide-related enzymes.

Basic Information

Product Name	L-α-Phosphatidylinositol-4-Phosphate (Brain, Porcine) (Ammonium Salt)
CAS No.	475995-51-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PI(4)P; Phosphatidylinositol 4-phosphate; PtdIns(4)P; 1,2-Diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate); L-α-Phosphatidylinositol-4-monophosphate; PIP; PI4P; Brain Phosphatidylinositol-4-Phosphate Ammonium Salt
EINECS	Contact for details

Quality Control

Our L-α-Phosphatidylinositol-4-Phosphate is produced and handled under strict quality protocols to ensure batch-to-batch consistency and purity suitable for sensitive research applications. Each lot is analyzed to confirm identity and purity, with comprehensive Certificates of Analysis (COA) documenting key parameters available upon request. We adhere to rigorous in-house standards to meet the exacting requirements of life science research.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and easily oxidized; therefore, containers should be sealed under vacuum or nitrogen after each use and allowed to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95% (Area %)
Solubility	Soluble in chloroform/methanol mixtures

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.