Description

1,2-Diphytanoyl-Sn-Glycero-3-[Phospho-L-Serine](Sodium Salt) is a chemically defined, synthetic phospholipid derivative of phosphatidylserine, featuring branched phytanoyl chains for enhanced membrane stability. This compound matters for researchers and formulators requiring a highly pure, structurally uniform lipid with superior resistance to oxidation and hydrolysis for creating robust, reproducible model membrane systems. It is essential for scientists in biophysics, structural biology, and pharmaceutical development who need precise control over lipid bilayer properties for studies on protein-lipid interactions, membrane dynamics, and advanced drug delivery platforms like liposomes.

Application

• Model Membrane Systems: A key component for constructing stable, oxidation-resistant planar lipid bilayers, black lipid membranes (BLMs), and supported lipid bilayers (SLBs) for biophysical research.
• Liposome & Nanocarrier Formulation: Used to engineer advanced liposomal and lipid nanoparticle (LNP) formulations with enhanced serum stability and controlled release profiles for drug and gene delivery applications.
• Protein-Lipid Interaction Studies: Essential for investigating the binding, folding, and functional modulation of membrane-associated proteins, peptides, and enzymes in a defined lipid environment.
• Cell Biology & Signaling Research: Serves as a critical tool for studying the role of phosphatidylserine exposure in cellular processes such as apoptosis, blood coagulation, and immune cell signaling.
• Biosensor & Diagnostic Development: Incorporated into lipid coatings for biosensors and diagnostic devices to improve biocompatibility, reduce non-specific binding, and enhance signal-to-noise ratios.
• Neuroscience Research: Applied in studies focusing on synaptic function, neuronal membrane integrity, and the role of phosphatidylserine in cognitive health.

Basic Information

Product Name	1,2-Diphytanoyl-Sn-Glycero-3-[Phospho-L-Serine](Sodium Salt)
CAS No.	474967-76-5
Molecular Formula	C46H88NNaO10P
Molecular Weight	893.15 g/mol
Synonyms	1,2-Diphytanoyl-sn-glycero-3-phospho-L-serine (sodium salt); DPhyPS (Na salt); PS(Phyt) (Sodium Salt); 1,2-Di(3,7,11,15-tetramethylhexadecanoyl)-sn-glycero-3-phospho-L-serine sodium salt; Phosphatidylserine, Diphytanoyl Derivative, Sodium Salt; Synthetic PS Lipid with Phytanoyl Chains; (2S)-2-Amino-3-({[(2R)-2,3-bis[(3R,7R,11R)-3,7,11,15-tetramethylhexadecanoyl]oxypropyl] phosphono}oxy)propanoic acid sodium salt
EINECS	Contact for details

Quality Control

Our synthetic phospholipids are produced under strict quality management to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and identity confirmation (NMR, MS). We provide full traceability and Certificates of Analysis (COA) detailing all relevant specifications. Production can adhere to GMP guidelines for applications requiring the highest level of documentation and control.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). For long-term storage, keep under an inert atmosphere (argon or nitrogen) to prevent oxidation. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Area %)
Water Content (KF)	≤ 1.0 %
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.