Description

1,2-Dipalmitoyl-Sn-Glycero-3-Phosphoethanolamine-n-[3-(2-Pyridyldithio)Propionate] (Sodium Salt) is a functionalized phospholipid derivative, specifically a heterobifunctional crosslinker containing a cleavable disulfide bond. This compound is critical for advanced bioconjugation strategies, enabling the controlled attachment of biomolecules to lipid-based delivery systems. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for developing targeted drug delivery platforms, liposomal formulations, and diagnostic reagents.

Application

• Liposome Surface Functionalization: Conjugation of targeting ligands (e.g., antibodies, peptides) to liposomal surfaces for active drug targeting.
• Nanoparticle Drug Delivery Systems: A key reagent for constructing stimuli-responsive nanocarriers where the disulfide bond cleaves in the reductive intracellular environment.
• Bioconjugation & Protein Labeling: Crosslinking agent for attaching proteins, enzymes, or other biomolecules to lipid membranes or other surfaces via thiol-reactive chemistry.
• Diagnostic Assay Development: Used in the preparation of lipid-based biosensors and immunoassay components.
• Cell Membrane Research: Tool for studying membrane dynamics, protein insertion, and cell-surface interactions.
• ADC (Antibody-Drug Conjugate) Linker Exploration: Model compound for investigating cleavable linker technologies in biotherapeutics.

Basic Information

Product Name	1,2-Dipalmitoyl-Sn-Glycero-3-Phosphoethanolamine-n-[3-(2-Pyridyldithio)Propionate] (Sodium Salt)
CAS No.	474944-16-6
Molecular Formula	C43H78N2O10PS2Na
Molecular Weight	909.18 g/mol
Synonyms	DPPE-PDP; 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[3-(2-pyridyldithio)propionate]; PDP-DPPE; N-[3-(2-Pyridyldithio)propionyl]-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine sodium salt; PDP-PE; SPDP-DPPE; Pyridyldithiopropionyl-DPPE; Heterobifunctional DPPE crosslinker
EINECS	Contact for details

Quality Control

Our 1,2-Dipalmitoyl-Sn-Glycero-3-Phosphoethanolamine-n-[3-(2-Pyridyldithio)Propionate] (Sodium Salt) is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and pharmaceutical development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation. For long-term storage, keep under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Pyridine-2-thione Release (UV)	Tested, data on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.