Description

1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanolamine-n-[3-(2-Pyridyldithio)Propionate] is a functionalized phospholipid derivative, widely recognized as a key reagent for constructing targeted drug delivery systems. Its core value lies in the pyridyldithiopropionate (PDP) group, which enables the formation of stable, cleavable disulfide bonds with thiol-containing molecules such as antibodies, peptides, and proteins. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who are developing advanced liposomal formulations, antibody-drug conjugates (ADCs), and other nanoparticle-based therapeutics.

Application

• Liposome Functionalization: A critical component for creating targeted liposomes by conjugating targeting ligands (e.g., antibodies, peptides) to the liposome surface via a cleavable linker.
• Antibody-Drug Conjugate (ADC) Linker Chemistry: Used to attach cytotoxic payloads to monoclonal antibodies through a reducible disulfide bond, facilitating controlled drug release in target cells.
• Nanoparticle Surface Modification: Enables the functionalization of polymeric or lipid nanoparticles with targeting moieties to enhance cell-specific delivery.
• Protein & Peptide Conjugation: Serves as a heterobifunctional crosslinker for coupling thiolated proteins or peptides to other molecules or surfaces.
• Diagnostic Agent Development: Utilized in the preparation of contrast agents or diagnostic probes for imaging applications, where targeted delivery is required.
• Cell Membrane Research: Employed in biophysical studies to incorporate specific functionalities into model lipid membranes.

Basic Information

Product Name	1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanolamine-n-[3-(2-Pyridyldithio)Propionate]
CAS No.	474944-13-3
Molecular Formula	C47H85N2O9PS2
Molecular Weight	917.32 g/mol
Synonyms	DOPE-PDP; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N-[3-(2-pyridyldithio)propionate]; PDP-DOPE; N-[3-(2-Pyridyldithio)propionyl]-1,2-dioleoyl-sn-glycero-3-phosphoethanolamine; Pyridyldithiopropionate-DOPE; Heterobifunctional PDP-PE; DSPE-PDP; PE-PDP
EINECS	Contact for details

Quality Control

Our 1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanolamine-n-[3-(2-Pyridyldithio)Propionate] is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. Allow the vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Solubility	Soluble in chloroform, DMSO, ethanol
Functional Group Integrity (PDP)	≥ 90% active
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.