Description

1,2-Dipalmitoyl-Sn-Glycero-3-Phosphoethanolamine-n-(Dodecanylamine) is a synthetic, amine-functionalized phospholipid derivative, a critical building block in advanced lipid-based formulations. Its unique structure, featuring a dodecylamine moiety, provides enhanced membrane interaction and functionalization capabilities, making it indispensable for creating stable, targeted delivery systems. This high-purity lipid is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for developing next-generation nanocarriers and biomimetic membranes.

Application

• Lipid Nanoparticle (LNP) Formulation: A key cationic/ionizable lipid component for the encapsulation and delivery of nucleic acids (mRNA, siRNA) in therapeutic and vaccine applications.
• Liposome & Niosome Development: Used to engineer stable, functionalized vesicles for targeted drug delivery, with the amine group enabling surface conjugation of targeting ligands or PEG chains.
• Gene Therapy Vectors: Essential for constructing non-viral transfection reagents and complexes that facilitate cellular uptake and endosomal escape of genetic material.
• Biomimetic Membrane Research: Serves as a model phospholipid in studies of membrane biophysics, protein-lipid interactions, and cellular signaling processes.
• Diagnostic Reagent Preparation: Incorporated into assay components and contrast agents for medical imaging and diagnostic tests.
• Cosmetic & Dermal Delivery Systems: Employed in high-end cosmetic formulations to create nanocarriers for improved skin penetration and stability of active ingredients.

Basic Information

Product Name	1,2-Dipalmitoyl-Sn-Glycero-3-Phosphoethanolamine-n-(Dodecanylamine)
CAS No.	474944-08-6
Molecular Formula	C49H99N2O8P
Molecular Weight	867.30 g/mol
Synonyms	DPPE-N-Dodecylamine; 1,2-Dihexadecanoyl-sn-glycero-3-phosphoethanolamine-N-dodecyl; N-Dodecyl-DPPE; DPPE-C12-Amine; PE(16:0/16:0)-N-C12; Phosphatidylethanolamine-N-dodecyl, dipalmitoyl; N-Dodecyl-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine; Amine-functionalized DPPE
EINECS	Contact for details

Quality Control

Our 1,2-Dipalmitoyl-Sn-Glycero-3-Phosphoethanolamine-n-(Dodecanylamine) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical and research applications. Certificates of Analysis (COA) with full traceability are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and hydrolysis. This material is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Solubility	Soluble in chloroform, methanol, DMSO
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.