Description

1-Stearoyl-2-Linoleoyl-Sn-Glycero-3-Phospho-(1'-Rac-Glycerol) (Sodium Salt) is a high-purity, synthetic phospholipid, specifically a phosphatidylglycerol (PG) sodium salt, with defined fatty acid chains at the sn-1 and sn-2 positions. This precise molecular structure is critical for advanced research and development in lipid-based formulations, offering superior batch-to-batch consistency and performance predictability. It is an essential raw material for scientists and formulators in the pharmaceutical, biotechnology, and advanced cosmetics industries, where it serves as a key component in liposomes, lipid nanoparticles (LNPs), and other sophisticated delivery systems.

Application

• Drug Delivery Systems: A critical excipient for formulating liposomal and lipid nanoparticle (LNP) carriers for mRNA, siRNA, and small molecule therapeutics.
• Biomembrane Research: Used as a standard or model phospholipid in biophysical studies to investigate membrane structure, fluidity, and protein-lipid interactions.
• Pulmonary Surfactant Mimetics: Serves as a key synthetic component in research focused on developing therapeutic surfactants for respiratory distress syndromes.
• Advanced Cosmetic Formulations: Incorporated into high-performance skincare products like nanosomes and ethosomes for enhanced active ingredient penetration and skin barrier repair.
• Diagnostic Reagents: Utilized in the development of diagnostic assays and kits that require specific lipid environments or liposome-based signal amplification.
• Cell Culture & Biotechnology: Employed in specialized media formulations and as a supplement to support the growth of certain fastidious cell types.

Basic Information

Product Name	1-Stearoyl-2-Linoleoyl-Sn-Glycero-3-Phospho-(1'-Rac-Glycerol) (Sodium Salt)
CAS No.	474943-26-5
Molecular Formula	C44H80NaO10P
Molecular Weight	822.06 g/mol (anhydrous)
Synonyms	18:0-18:2 PG (Na Salt); 1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphoglycerol sodium salt; PG(18:0/18:2(9Z,12Z)) sodium salt; Phosphatidylglycerol (18:0/18:2) sodium salt; SLPG; 1-Octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-rac-glycerol) sodium salt; (R)-2,3-Di(octadeca-9,12-dienoyloxy)propyl (2,3-dihydroxypropyl) phosphate sodium salt
EINECS	Contact for details

Quality Control

Every batch of our synthetic phospholipids is manufactured under strict quality management systems. The product undergoes comprehensive analytical characterization using techniques including HPLC, NMR, and MS to confirm identity, purity, and fatty acid composition. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes batch-specific data on assay, impurities, and critical physical parameters. Our production adheres to cGMP guidelines where applicable, ensuring material suitable for demanding pharmaceutical and biomedical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. For long-term storage, desiccate at -20°C. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Fatty Acid Composition (GC)	Stearic acid (C18:0): ~45-55%; Linoleic acid (C18:2): ~45-55%
Water Content (KF)	≤ 3.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.