Description

1,2-Diarachidonoyl-Sn-Glycero-3-[Phospho-Rac-(1-Glycerol)] (Sodium Salt) is a high-purity, synthetic phospholipid derivative, specifically a sodium salt of phosphatidylglycerol with arachidonic acid chains. This compound is a critical biochemical tool and precursor for advanced research into lipid signaling, membrane biophysics, and eicosanoid biosynthesis pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and specialty chemical manufacturers focused on lipidomics, drug delivery systems, and inflammatory disease modeling.

Application

• Lipidomics & Biochemical Research: Serves as a standard and substrate for studying phospholipase A2 (PLA2) activity, lipid second messengers, and eicosanoid production.
• Drug Delivery System Development: Used in the formulation and study of liposomes and lipid nanoparticles (LNPs) for targeted therapeutic delivery.
• Cell Membrane & Model System Studies: A key component for constructing synthetic membranes to investigate lipid-protein interactions and membrane fluidity.
• Inflammation & Immunology Research: Acts as a precursor for pro-inflammatory lipid mediators, aiding in the study of pathways related to asthma, arthritis, and other inflammatory conditions.
• Pharmaceutical Reference Standard: Employed as a certified reference material (CRM) for quality control and analytical method development in lipid-based pharmaceuticals.
• Enzymology Assays: Used as a specific substrate in high-throughput screening assays for enzyme inhibitors targeting phospholipid metabolism.

Basic Information

Product Name	1,2-Diarachidonoyl-Sn-Glycero-3-[Phospho-Rac-(1-Glycerol)] (Sodium Salt)
CAS No.	474943-21-0
Molecular Formula	C47H77NaO10P
Molecular Weight	855.08 g/mol
Synonyms	1,2-Di(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt); PG(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z)); Phosphatidylglycerol (20:4/20:4) Sodium Salt; 1,2-Diarachidonoylphosphatidylglycerol Sodium Salt; AA-PG; Sodium 1,2-diarachidonoyl-sn-glycero-3-phosphoglycerol; (2R)-2,3-Bis[[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyl]oxy]propyl 2,3-dihydroxypropyl phosphate sodium salt
EINECS	Contact for details

Quality Control

Our 1,2-Diarachidonoyl-Sn-Glycero-3-[Phospho-Rac-(1-Glycerol)] (Sodium Salt) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical parameters such as assay, lipid profile, and solvent residues.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen). The product is hygroscopic (moisture-sensitive) and easily oxidized; allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and degradation.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95%
1-Acyl/2-Acyl Isomer Ratio	Specified on COA
Solvent Residues	Meets ICH guidelines
Water Content (KF)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.