Description

1,2-Dipalmitoyl-Sn-Glycero-3-Phosphoethanolamine-n-(Glutaryl) (Sodium Salt) is a high-purity, synthetic phospholipid derivative, specifically a glutarylated phosphatidylethanolamine. This compound is a critical functional intermediate for advanced drug delivery systems, enabling the precise modification of liposome surfaces for targeted therapeutic applications. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing next-generation nanomedicines, diagnostic agents, and vaccine adjuvants.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: A key building block for the synthesis of functionalized phospholipids used in liposomal drug formulations.
• Targeted Drug Delivery Systems: Used to conjugate targeting ligands (e.g., antibodies, peptides) to liposome surfaces for site-specific therapy in oncology and other diseases.
• Long-Circulating "Stealth" Liposomes: Serves as a linker molecule for attaching polyethylene glycol (PEG) or other polymers to enhance circulation time and reduce immune clearance.
• Diagnostic Imaging Agents: Facilitates the attachment of contrast agents or radiolabels to lipid nanoparticles for MRI, CT, or nuclear imaging.
• Vaccine Adjuvant Development: Employed in the design of novel lipid-based adjuvant systems to improve immune response.
• Gene Therapy Vectors: Used in the formulation of lipid nanoparticles (LNPs) for the safe and efficient delivery of nucleic acids (siRNA, mRNA, DNA).
• Bioconjugation & Surface Chemistry: Provides a reactive carboxyl group (via the glutaryl moiety) for coupling biomolecules in research and diagnostic kit development.

Basic Information

Product Name	1,2-Dipalmitoyl-Sn-Glycero-3-Phosphoethanolamine-n-(Glutaryl) (Sodium Salt)
CAS No.	474923-45-0
Molecular Formula	C42H79NNaO12P
Molecular Weight	844.04 g/mol
Synonyms	DPPE-Glutaryl (Sodium Salt); 1,2-Dihexadecanoyl-sn-glycero-3-phosphoethanolamine-N-glutaryl (Sodium Salt); Glutaryl-DPPE, Na Salt; N-Glutaryl-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine Sodium Salt; DPPE-GA; Phosphatidylethanolamine-N-glutaryl, Dipalmitoyl Derivative; PE(16:0/16:0)-Glutaryl; N-(3-Carboxy-1-oxopropyl)-1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine Sodium Salt
EINECS	Contact for details

Quality Control

Our 1,2-Dipalmitoyl-Sn-Glycero-3-Phosphoethanolamine-n-(Glutaryl) (Sodium Salt) is manufactured under strict quality systems suitable for pharmaceutical R&D and GMP applications. Each batch undergoes rigorous analytical testing including HPLC for purity and identity, NMR for structural confirmation, and mass spectrometry. Certificates of Analysis (COA) with full traceability are provided, ensuring compliance with critical regulatory and research standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This material is hygroscopic (moisture-sensitive). For long-term storage, keep under an inert atmosphere (argon or nitrogen). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Area %)
Water Content (KF)	≤ 3.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.