Description

1,2-Dipalmitoyl-Sn-Glycero-3-Phosphothioethanol (Sodium Salt) is a high-purity, synthetic phospholipid derivative, specifically a thiol-reactive phosphatidylethanolamine. This compound is a critical reagent for the functionalization and stabilization of surfaces and nanoparticles in advanced bioconjugation and materials science. It is primarily utilized by researchers and manufacturers in the pharmaceutical, diagnostic, and nanotechnology sectors who require precise, reproducible surface chemistry for creating stable liposomes, biosensors, and targeted drug delivery systems.

Application

• Liposome and Lipid Nanoparticle (LNP) Formulation: As a functional component to introduce thiol groups for surface modification, cross-linking, or ligand attachment in drug delivery vehicles.
• Biosensor and Biochip Development: For creating self-assembled monolayers (SAMs) on gold or other metal surfaces to immobilize biomolecules for diagnostic assays.
• Nanoparticle Functionalization: To coat and stabilize metallic (e.g., gold) or quantum dot nanoparticles, providing a biocompatible phospholipid layer with reactive thiol terminals.
• Membrane Protein Studies: Used in model membrane systems (e.g., supported lipid bilayers) to study protein-lipid interactions and membrane dynamics.
• Targeted Drug Delivery: Enables the covalent attachment of targeting peptides, antibodies, or other ligands to liposomal surfaces for active targeting.
• Bioconjugation Chemistry: Serves as a key intermediate for coupling phospholipids to other molecules via thiol-maleimide or thiol-disulfide exchange reactions.

Basic Information

Product Name	1,2-Dipalmitoyl-Sn-Glycero-3-Phosphothioethanol (Sodium Salt)
CAS No.	474923-39-2
Molecular Formula	C37H72NNaO7PS
Molecular Weight	743.97 g/mol
Synonyms	DPPE-Thiol (Sodium Salt); 1,2-Dipalmitoyl-sn-glycero-3-phosphothioethanol, Na Salt; 16:0 PE-Thiol; Phosphatidylethanolamine-N-[2-amino-1-thioethyl] (sodium salt); DPPE-SH; 1,2-Dihexadecanoyl-sn-glycero-3-phosphothioethanol sodium salt; Thiolated DPPE; Sodium 1,2-dipalmitoyl-sn-glycero-3-phosphothioethanolate
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to guarantee identity, purity, and performance consistency suitable for research and GMP-grade manufacturing. Certificates of Analysis (COA) detailing specific lot results for assay, impurities, and critical physical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. This material is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (TLC)	Single major spot
Water Content (KF)	≤ 2.0%
Solubility	Soluble in chloroform, methanol, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.