Description

1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanolamine-n-[Methoxy(Polyethylene Glycol)-350] (Ammonium Salt) is a high-purity, synthetic phospholipid-PEG conjugate, widely recognized as a critical functional excipient in advanced pharmaceutical formulations. Its primary value lies in its ability to impart stealth properties and enhance the stability of lipid-based drug delivery systems, thereby improving therapeutic efficacy and circulation time. This material is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing liposomal, nanoparticle, and other nanomedicine platforms.

Application

• Liposomal Drug Delivery: As a key component of PEGylated (stealth) liposomes to reduce opsonization and prolong systemic circulation for chemotherapeutics, antibiotics, and gene therapies.
• Nanoparticle Stabilization: Used to coat the surface of polymeric or lipid nanoparticles (LNPs, SLNs) to prevent aggregation, improve colloidal stability, and provide a hydrophilic protective layer.
• mRNA & Gene Delivery Systems: A vital constituent in the lipid bilayer of lipid nanoparticles (LNPs) for mRNA vaccines and other nucleic acid delivery applications, contributing to stability and efficacy.
• Diagnostic Agent Formulation: Employed in the development of contrast agents for medical imaging (e.g., MRI, ultrasound) to enhance biocompatibility and targeting.
• Bioconjugation & Surface Modification: Serves as an anchor for attaching targeting ligands (antibodies, peptides) or other functional molecules to lipid-based carriers.
• Cosmetic & Dermal Formulations: Used in advanced cosmetic products like nanocarriers for the sustained release of active ingredients (vitamins, antioxidants).

Basic Information

Product Name	1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanolamine-n-[Methoxy(Polyethylene Glycol)-350] (Ammonium Salt)
CAS No.	474922-82-2
Molecular Formula	C81H158N2O19P
Molecular Weight	~1470.1 g/mol (Average)
Synonyms	DOPE-PEG(350); 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-350]; PEG350-DOPE; mPEG350-DOPE; Ammonium salt of PEGylated DOPE; DSPE-PEG(350) (structural analog); Polyethylene glycol (350) derivative of DOPE; PEGylated phospholipid (350 MW)
EINECS	Contact for details

Quality Control

Our 1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanolamine-n-[Methoxy(Polyethylene Glycol)-350] (Ammonium Salt) is manufactured under strict quality systems to ensure consistency and reliability for critical research and GMP-grade applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as purity, lipid content, and functional integrity. We adhere to relevant ICH guidelines and support customer audits to meet the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This material is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
PEG Content	~350 Da (by NMR)
Residual Solvents (GC)	Meets ICH limits
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 10 ppm
Bacterial Endotoxins	< 5.0 EU/mg (for injectable grade)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.