Description

Dspe-Peg-Nh2 CAS NO 474922-26-4 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a distearoylphosphatidylethanolamine (DSPE) lipid anchor and a primary amine (NH2) functional group at the distal end of the PEG chain. This unique structure is critical for creating stable, long-circulating, and targetable nanocarriers in advanced drug delivery systems. It is an essential building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing next-generation therapeutics, including liposomal formulations, lipid nanoparticles (LNPs), and targeted conjugates.

Application

• Lipid Nanoparticle (LNP) and Liposomal Drug Delivery: Serves as a key functionalized lipid-PEG conjugate (PEG-lipid) to impart stealth properties (preventing rapid clearance) and provide a reactive amine handle for surface functionalization of nanoparticles used in mRNA vaccines, siRNA delivery, and chemotherapeutic agents.
• Active Targeting Conjugates: The primary amine group allows for covalent conjugation to targeting ligands (e.g., antibodies, peptides, folates) to create actively targeted drug delivery systems that home in on specific cells or tissues.
• Surface Modification of Nanocarriers: Used to introduce reactive amine groups onto the surface of pre-formed liposomes or micelles for subsequent cross-linking or attachment of diagnostic or therapeutic payloads.
• Stabilization of Emulsions and Micelles: The DSPE moiety integrates into lipid membranes, while the hydrophilic PEG chain extends into the aqueous phase, providing steric stabilization to colloidal systems.
• Bioconjugation and Linker Chemistry: Acts as a versatile heterobifunctional linker for connecting lipid-based structures to a wide range of amine-reactive molecules, dyes, or drugs.
• Research & Development: A critical reagent in academic and industrial R&D for prototyping novel nanomedicines and studying PEGylation effects on pharmacokinetics and biodistribution.

Basic Information

Product Name	Dspe-Peg-Nh2
CAS No.	474922-26-4
Molecular Formula	CnH2n+1NOmP (Variable based on PEG chain length)
Molecular Weight	Variable (Typically 2000-5000 g/mol, depending on PEG unit count)
Synonyms	1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)]; DSPE-PEG-Amine; DSPE-PEG-NH2; DSPE-PEGn-NH2; Phosphatidylethanolamine-PEG-Amine; PEGylated DSPE amine; Amine-PEG-DSPE; Lipid-PEG-Amine; NH2-PEG-DSPE
EINECS	Contact for details

Quality Control

Our Dspe-Peg-Nh2 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, consistent molecular weight distribution, and functional group integrity. Key parameters monitored include PEG chain length (n value) distribution, degree of amine functionalization, and lipid purity. Certificates of Analysis (COA) detailing specifications such as NMR purity, HPLC assay, and functional group substitution rate are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to warm to room temperature before opening to prevent condensation. For long-term storage, keep under an inert atmosphere (argon or nitrogen).

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (NMR)	Conforms to structure
PEG Average Molecular Weight (n)	2000, 3400, 5000 (or as requested)
Purity (HPLC)	≥ 95%
Amine Substitution	≥ 90%
Water Content (KF)	≤ 1.0%
Solvents (Residual)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.