Description

1,2-Distearoyl-Sn-Glycero-3-Phosphoethanolamine-n-[Carboxy(Polyethylene Glycol)-2000] (Ammonium Salt) is a high-purity, functionalized phospholipid-PEG conjugate, widely recognized as a critical component in advanced drug delivery and diagnostic systems. Its primary value lies in its ability to impart stealth properties and active targeting capabilities to lipid-based nanoparticles, significantly enhancing their circulation time and therapeutic efficacy. This material is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing next-generation liposomal drugs, mRNA vaccines, and targeted imaging agents.

Application

• Lipid Nanoparticle (LNP) Formulation: A key functional excipient for creating PEGylated, long-circulating LNPs used in siRNA, mRNA, and gene delivery vehicles.
• Stealth Liposomes: Imparts "stealth" characteristics to therapeutic liposomes by forming a protective hydrophilic PEG corona, reducing recognition by the mononuclear phagocyte system (MPS).
• Active Targeting Conjugation: The terminal carboxylic acid group enables covalent attachment of targeting ligands (e.g., antibodies, peptides, folates) for site-specific drug delivery.
• Diagnostic Agent Stabilization: Used to stabilize and functionalize micelles and other nanocarriers for contrast agents in medical imaging (MRI, ultrasound).
• Surface Modification: Modifies the surface properties of materials and implants to improve biocompatibility and reduce protein adsorption.
• Research & Development: A vital tool in academic and industrial R&D for exploring novel nanomedicine constructs and delivery mechanisms.

Basic Information

Product Name	1,2-Distearoyl-Sn-Glycero-3-Phosphoethanolamine-n-[Carboxy(Polyethylene Glycol)-2000] (Ammonium Salt)
CAS No.	474922-20-8
Molecular Formula	C~125H~250N2O~55P * xNH3
Molecular Weight	~2800 g/mol (PEG M.W. ~2000)
Synonyms	DSPE-PEG(2000)-COOH; DSPE-PEG2k-Carboxylic Acid; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)-2000]; DSPE-PEG(2000)-Acid; Ammonium salt of DSPE-PEG2k-COOH; PEG2000-DSPE-COOH; Phospholipid-PEG-carboxyl; COOH-PEG2000-DSPE
EINECS	Contact for details

Quality Control

Our 1,2-Distearoyl-Sn-Glycero-3-Phosphoethanolamine-n-[Carboxy(Polyethylene Glycol)-2000] (Ammonium Salt) is manufactured under strict quality systems suitable for pharmaceutical R&D and formulation. Each batch undergoes rigorous analytical testing to ensure identity, purity, and functional integrity. Certificates of Analysis (COA) are provided, detailing key parameters such as assay (HPLC), degree of substitution, acid value, and critical impurity profiles. We support compliance with relevant guidelines for excipients used in advanced therapeutic medicinal products (ATMPs).

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This material is hygroscopic (moisture-sensitive). For long-term storage, keep under an inert atmosphere (e.g., argon or nitrogen). Allow the sealed container to reach room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White or off-white solid/waxy solid
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 95.0%
PEG Molecular Weight (NMR/SEC)	1900 - 2100 Da
Acid Value	Contact for details
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Functional Group Substitution	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.