Description

(S)-Cbs-Borane Complex CAS NO 461412-21-5 is a highly effective, enantioselective organoboron reagent used as a catalyst or stoichiometric reducing agent in asymmetric synthesis. Its core value lies in enabling the production of chiral alcohols and amines with exceptional enantiomeric purity, which is critical for developing active pharmaceutical ingredients (APIs) and advanced fine chemicals. This complex is essential for R&D and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-performance chiral auxiliaries for complex synthetic routes.

Application

• Asymmetric Reduction of Prochiral Ketones: Key for synthesizing enantiomerically pure secondary alcohols, a fundamental building block in pharmaceutical intermediates.
• Chiral Auxiliary in API Synthesis: Employed in the critical steps of manufacturing optically active drug candidates and approved active pharmaceutical ingredients (APIs).
• Agrochemical Intermediate Production: Used to create chiral active ingredients for herbicides, fungicides, and pesticides with improved efficacy and environmental profile.
• Fine Chemical and Fragrance Synthesis: Facilitates the production of high-value chiral compounds for flavors, fragrances, and advanced material precursors.
• Academic and Industrial R&D: A vital tool for methodological development in organic chemistry and process chemistry optimization.
• Catalyst Ligand Preparation: Serves as a precursor or modifying agent for other chiral catalysts and ligands used in transition metal catalysis.

Basic Information

Product Name	(S)-Cbs-Borane Complex
CAS No.	461412-21-5
Molecular Formula	C₁₈H₂₁BN₂
Molecular Weight	276.19 g/mol
Synonyms	(S)-2-Methyl-CBS-oxazaborolidine; (S)-CBS Catalyst; (S)-Corey-Bakshi-Shibata Borane Complex; (S)-Tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole-borane; (S)-MeCBS; (S)-Oxazaborolidine-Borane Complex; (S)-2-Methyl-CBS-Borane; (S)-CBS-BH₃ Complex
EINECS	Contact for details

Quality Control

Our (S)-Cbs-Borane Complex is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC, NMR, and titration methods, to confirm identity, purity, and activity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry place. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or ambient temperature will compromise its efficacy. Keep the original container sealed and allow it to reach room temperature in a dry environment before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (ee)	≥ 99.0%
Assay (Titration)	95.0 - 105.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.