Description

n-(Carboxymethyl)-n-[6-(2,5-Dihydro-2,5-Dioxo-1H-Pyrrol-1-Yl)Hexyl]- Glycine is a specialized functionalized amino acid derivative that serves as a high-value intermediate and building block in advanced chemical synthesis. Its molecular structure, featuring both a maleimide and a glycine moiety, makes it a critical component for creating targeted bioconjugates and functional polymers. This compound is essential for R&D and production teams in the pharmaceutical, biotech, and advanced materials sectors who require precise and reliable coupling agents.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Linker: A key intermediate for constructing cleavable or non-cleavable linkers in targeted cancer therapies, connecting cytotoxic payloads to monoclonal antibodies.
• Protein and Peptide Modification: Used to introduce functional handles (e.g., for fluorescence labeling, PEGylation, or surface immobilization) onto proteins via reaction with cysteine thiol groups.
• Polymer Functionalization: Serves as a monomer or cross-linking agent for synthesizing smart hydrogels, responsive materials, and functional coatings with tailored properties.
• Diagnostic Reagent Synthesis: Employed in the development of contrast agents, imaging probes, and assay components for medical diagnostics and research.
• Surface Chemistry and Immobilization: Facilitates the covalent attachment of biomolecules (enzymes, antibodies) to chips, beads, and other solid supports for biosensors and affinity purification.
• Chemical Biology Research: A valuable tool for studying protein interactions, cellular pathways, and for developing novel probe molecules in academic and industrial research settings.

Basic Information

Product Name	n-(Carboxymethyl)-n-[6-(2,5-Dihydro-2,5-Dioxo-1H-Pyrrol-1-Yl)Hexyl]- Glycine
CAS No.	445390-53-4
Molecular Formula	C15H22N2O6
Molecular Weight	326.35 g/mol
Synonyms	N-(Carboxymethyl)-N-[6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexyl]glycine; Maleimide-C6-EDTA; 1-[6-[Carboxymethyl(methylcarbamoylmethyl)amino]hexyl]-1H-pyrrole-2,5-dione; 6-Maleimidocaproic acid EDTA derivative; N-(6-Maleimidocaproyl)-EDTA; Maleimide-PEG6-acid analog; Maleimide hexanoic acid EDTA amide; N-[(6-Maleimido-1-oxohexyl)]-N-(carboxymethyl)glycine
EINECS	Contact for details

Quality Control

Every batch of n-(Carboxymethyl)-n-[6-(2,5-Dihydro-2,5-Dioxo-1H-Pyrrol-1-Yl)Hexyl]- Glycine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the identity, purity, and consistency required for sensitive applications like bioconjugation. Certificates of Analysis (COA) detailing HPLC purity, NMR confirmation, and other critical parameters are available for each lot. Our quality commitment supports compliance with cGMP and ISO 9001 standards for research and pharmaceutical intermediate use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation. Keep under inert atmosphere (e.g., nitrogen or argon) for optimal shelf life.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.