Description

3'-o-Levulinyl-2'-Deoxyadenosine is a high-purity, chemically modified nucleoside derivative, specifically designed for advanced oligonucleotide synthesis. This compound matters as a critical building block for the production of antisense oligonucleotides, siRNA, and other therapeutic nucleic acids, where it acts as a versatile protecting group. It is essential for pharmaceutical R&D laboratories, biotechnology companies, and CDMOs engaged in the development of next-generation genetic medicines and molecular diagnostics. The product is supplied with a focus on batch-to-batch consistency and low bioburden to support cGMP manufacturing processes.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): A key phosphoramidite precursor for the automated synthesis of therapeutic oligonucleotides.
• Antisense Oligonucleotide (ASO) Development: Used in the research and GMP production of ASOs targeting various genetic disorders.
• Small Interfering RNA (siRNA) Manufacturing: Serves as a protected monomer unit in the synthesis of siRNA duplexes for gene silencing applications.
• Diagnostic Probe Synthesis: Employed in creating labeled probes for PCR, FISH, and other molecular diagnostic assays.
• Academic & Pharmaceutical Research: A vital reagent for studying nucleic acid chemistry, stability, and novel drug delivery mechanisms.
• Contract Development and Manufacturing (CDMO): Supplied as a reliable raw material for scale-up and commercial manufacturing of nucleic acid-based therapeutics.

Basic Information

Product Name	3'-o-Levulinyl-2'-Deoxyadenosine
CAS No.	440327-45-7
Molecular Formula	C17H19N5O5
Molecular Weight	373.37 g/mol
Synonyms	2'-Deoxyadenosine, 3'-(4-oxopentanoate); 3'-O-(4-Oxopentanoyl)-2'-deoxyadenosine; 3'-O-Levulinyl-2'-deoxyadenosine; 3'-Levulinyl-dA; 3'-O-Lev-dA; N6-Benzoyl-3'-O-levulinyl-2'-deoxyadenosine (protected form variant); 2'-Deoxy-3'-O-levulinyladenosine
EINECS	Contact for details

Quality Control

Every batch of 3'-o-Levulinyl-2'-Deoxyadenosine is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing, including HPLC, NMR, and mass spectrometry, to ensure compliance with industry standards for nucleic acid synthesis. Certificates of Analysis (COA) with detailed chromatographic purity, water content, and residual solvent data are available upon request. We support development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.