Description

1,2,5-Tri-o-Butyryl-Myo-Inositol 3,4,6-Trisphosphate-Hexakis(Acetoxymethyl) Ester is a specialized, cell-permeable derivative of inositol trisphosphate (IP3), designed for advanced biochemical and pharmacological research. This compound serves as a critical tool for studying intracellular calcium signaling pathways, offering enhanced stability and delivery into live cells. It is primarily utilized by research scientists and pharmaceutical developers in the fields of cell biology, neuroscience, and drug discovery for investigating receptor-mediated signal transduction.

Application

• Intracellular Calcium Signaling Research: Used as a membrane-permeable precursor to generate IP3 within cells, triggering calcium release from the endoplasmic reticulum.
• Pharmacological Studies: Employed to investigate the function and modulation of IP3 receptors (IP3R) in various cell types and disease models.
• Neuroscience and Cell Biology: A key reagent for studying synaptic plasticity, neuronal communication, and other calcium-dependent cellular processes.
• Drug Discovery Screening: Utilized in high-throughput assays to identify novel compounds that target the IP3 signaling cascade for therapeutic intervention.
• Biochemical Pathway Analysis: Facilitates the mapping of downstream effects of IP3-mediated calcium mobilization on cellular functions like metabolism, gene expression, and apoptosis.

Basic Information

Product Name	1,2,5-Tri-o-Butyryl-Myo-Inositol 3,4,6-Trisphosphate-Hexakis(Acetoxymethyl) Ester
CAS No.	431900-03-7
Molecular Formula	C41H67O27P3
Molecular Weight	1084.88 g/mol
Synonyms	IP3 Hexakis(acetoxymethyl) Ester, Butyryl Derivative; myo-Inositol 1,4,5-trisphosphate, 1,2,5-tri-O-butyryl-3,4,6-tris[phosphonooxy] hexakis(acetoxymethyl) ester; Hexa-AM ester of IP3; Cell-permeable IP3 analog; D-myo-Inositol 1,4,5-trisphosphate, P1,P2,P3-(hexakis(acetoxymethyl)) ester, 1,2,5-tri-O-butyryl-; caged IP3 analog (butyryl protected)
EINECS	Contact for details

Quality Control

This high-purity biochemical is manufactured under strict quality control protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Product identity and purity are verified by advanced analytical techniques including NMR and HPLC. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your research documentation and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep under an inert atmosphere. Allow the vial to reach room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.