Description

Biotinyl Tobramycin Amide is a chemically modified derivative of the aminoglycoside antibiotic tobramycin, covalently linked to biotin. This molecular conjugate is specifically designed for advanced research applications, enabling the targeted study of tobramycin's interactions and mechanisms. It serves as a critical tool for scientists in pharmaceutical R&D and life sciences, particularly in the development of novel detection systems and targeted therapeutic strategies.

Application

• Biochemical Research Probe: Used as a molecular probe to study the binding affinity, localization, and transport mechanisms of tobramycin derivatives in biological systems.
• Diagnostic Assay Development: Serves as a key intermediate or labeled component in the development of sensitive immunoassays or biosensors for antibiotic detection.
• Affinity Chromatography Ligand: Immobilized on solid supports (e.g., streptavidin-coated beads) for the purification or isolation of specific biological targets that interact with aminoglycosides.
• Drug Targeting and Conjugate Synthesis: Acts as a building block for creating more complex drug-biomolecule conjugates aimed at improving drug delivery or specificity.
• Mechanistic Studies in Microbiology: Facilitates research into bacterial resistance mechanisms and the molecular pathways of aminoglycoside antibiotics.

Basic Information

Product Name	Biotinyl Tobramycin Amide
CAS No.	419573-18-5
Molecular Formula	C35H62N8O13S
Molecular Weight	810.98 g/mol
Synonyms	Biotin-Tobramycin; Tobramycin-Biotin Conjugate; Tobramycin Amide, Biotinyl Derivative; N-Biotinyltobramycin Amide; Biotinylated Tobramycin; 5-[(3aS,4S,6aR)-2-Oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[1-[[(2S,3S,4R,5S)-5-amino-2-[[(2S,3S,6S)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy]-3,4-dihydroxy-tetrahydrofuran-3-yl]amino]-3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57,58-icosaoxa-60-azahenhexacontan-60-yl]pentanamide (long-form IUPAC); Biotin-Tobra; Research Grade Biotin-Tobramycin
EINECS	Contact for details

Quality Control

Our Biotinyl Tobramycin Amide is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (Mass Spec)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.