Description

Casopitant is a potent and selective neurokinin-1 (NK1) receptor antagonist, a compound of significant interest in pharmaceutical research and development. Its primary value lies in its potential therapeutic applications for the treatment of chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV). This high-purity intermediate is essential for researchers and manufacturers in the global pharmaceutical industry engaged in the synthesis of novel antiemetic drugs and advanced clinical studies.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) targeting the NK1 receptor.
• Antiemetic Drug Development: Core research material for developing next-generation treatments for chemotherapy-induced nausea and vomiting (CINV).
• Clinical Research: Used in the preparation of formulations for preclinical and clinical trial studies.
• Neurological Research: A valuable tool compound for studying the role of substance P and NK1 receptors in the central nervous system.
• Process Chemistry & Scale-up: Serves as a critical reference standard and starting material for process optimization and commercial-scale manufacturing.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	Casopitant
CAS No.	414910-30-8
Molecular Formula	C23H28FN3O2
Molecular Weight	397.49 g/mol
Synonyms	GW679769; GW-679769; (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholin-4-ylmethylmorpholine; 4-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]morpholine; NK1 Receptor Antagonist GW679769
EINECS	Contact for details

Quality Control

Our Casopitant is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and related substances, residual solvent analysis, and identity confirmation (IR, NMR). A Certificate of Analysis (COA) detailing all specifications and results is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.