Description

5'-o-(4,4-Dimethoxytrityl)-Thymidine-3'-Succinate, Tea Salt is a high-purity, protected nucleoside derivative essential for oligonucleotide synthesis. This compound serves as a critical building block in solid-phase phosphoramidite chemistry, enabling the precise assembly of DNA sequences. It is primarily required by biotechnology, pharmaceutical, and diagnostic industries for research, therapeutic development, and molecular diagnostics.

Application

• Oligonucleotide Synthesis: As a key phosphoramidite precursor for the automated synthesis of DNA strands.
• Antisense Drug Development: For the research and production of antisense oligonucleotides and siRNA therapeutics.
• Molecular Diagnostics: In the manufacture of probes and primers for PCR, sequencing, and genetic testing.
• Research Reagents: As a specialized intermediate for academic and industrial research in molecular biology and genetics.
• Therapeutic API Synthesis: As a starting material or intermediate in the synthesis of complex nucleoside-based active pharmaceutical ingredients (APIs).

Basic Information

Product Name	5'-o-(4,4-Dimethoxytrityl)-Thymidine-3'-Succinate, Tea Salt
CAS No.	402944-22-3
Molecular Formula	C37H40N2O11
Molecular Weight	688.72 g/mol
Synonyms	5'-O-DMT-Thymidine-3'-succinate, Triethylammonium Salt; DMT-dT-succinate, TEA Salt; 5'-O-(4,4'-Dimethoxytrityl)thymidine-3'-succinic Acid Triethylammonium Salt; Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-(hydrogen succinate), compd. with N-ethylethanamine (1:1); DMT-dT-Suc-TEA; Protected Thymidine Succinate; Nucleoside Derivative for Oligo Synthesis
EINECS	Contact for details

Quality Control

Our 5'-o-(4,4-Dimethoxytrityl)-Thymidine-3'-Succinate, Tea Salt is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive oligonucleotide synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and critical impurity profiles. We adhere to GMP principles and can support documentation for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This material is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation. For long-term storage, keep under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.