Description

Nitrilotriacetic Acid Tri(n-Succinimidyl) is a specialized, high-purity chemical intermediate designed for advanced bioconjugation and crosslinking applications. This compound matters for its ability to provide a stable, tri-functional reactive platform for attaching biomolecules, enabling the development of sophisticated diagnostic and therapeutic agents. It is primarily needed by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic industries who require precise and reliable conjugation chemistry.

Application

• Bioconjugation Reagent: Used as a key intermediate for creating tri-functional crosslinkers to attach proteins, antibodies, or peptides to surfaces, nanoparticles, or other biomolecules.
• Diagnostic Assay Development: Essential for constructing sensitive immunoassays (e.g., ELISA) and biosensors by facilitating the stable immobilization of capture antibodies.
• Antibody-Drug Conjugate (ADC) Research: Serves as a building block in the synthesis of novel linker-payload systems for targeted cancer therapies.
• Biomaterial Functionalization: Enables the surface modification of polymers, hydrogels, and medical devices with bioactive molecules to enhance biocompatibility and functionality.
• Protein Labeling and Tagging: Facilitates the introduction of fluorescent dyes, affinity tags (e.g., biotin), or other probes onto proteins for detection and purification studies.
• Affinity Chromatography Ligand Synthesis: Used in the preparation of specialized resins for the purification of specific proteins or enzymes.

Basic Information

Product Name	Nitrilotriacetic Acid Tri(n-Succinimidyl)
CAS No.	401514-72-5
Molecular Formula	C18H18N4O12
Molecular Weight	482.36 g/mol
Synonyms	NTA Tris(NHS Ester); Nitrilotriacetic Acid Tris(N-hydroxysuccinimide Ester); Tris(N-succinimidyl) Nitrilotriacetate; N,N-Bis[2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-2-oxoethyl]glycine 2,5-dioxo-1-pyrrolidinyl ester; 2,2',2''-Nitrilotriacetic Acid Tris(N-succinimidyl Ester); NTA Tris(succinimidyl ester); NTA Tri(NHS); Tris-NHS-NTA
EINECS	Contact for details

Quality Control

Our Nitrilotriacetic Acid Tri(n-Succinimidyl) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive research and production applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation. Certificates of Analysis (COA) with detailed specifications are provided to guarantee compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO; slightly soluble in acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.