Description

Z-L-p-Fluoro-Phe-Chloromethylketone is a specialized chloromethyl ketone derivative of a fluorinated phenylalanine amino acid, serving as a potent and selective irreversible inhibitor for serine proteases. This compound is critical for biochemical research and pharmaceutical development, enabling precise study and modulation of enzymatic pathways. It is primarily utilized by researchers and manufacturers in the fields of protease inhibitor development, peptide synthesis, and medicinal chemistry for drug discovery programs.

Application

• Protease Inhibitor Research: Acts as an active site-directed irreversible inhibitor for studying serine proteases like trypsin, chymotrypsin, and related enzymes.
• Medicinal Chemistry & Drug Discovery: Serves as a key pharmacophore or building block in the design and synthesis of novel therapeutic agents targeting protease activity.
• Biochemical Assay Development: Used as a reference standard or tool compound in enzymatic assays to validate mechanisms and measure inhibition kinetics.
• Peptide Synthesis & Modification: Employed as an intermediate for introducing the p-fluoro-phenylalanine chloromethyl ketone moiety into more complex peptide structures.
• Apoptosis & Cell Signaling Studies: Utilized to investigate the role of specific proteases in cellular processes such as programmed cell death.

Basic Information

Product Name	Z-L-p-Fluoro-Phe-Chloromethylketone
CAS No.	400771-48-4
Molecular Formula	C19H17ClFNO4
Molecular Weight	377.79 g/mol
Synonyms	Z-L-4-Fluorophenylalanine Chloromethyl Ketone; N-Carbobenzoxy-L-4-fluorophenylalanyl Chloromethyl Ketone; Z-F-F-CK; Z-Phe(4-F)-CH2Cl; Benzyloxycarbonyl-L-p-fluorophenylalanyl chloromethyl ketone; Nα-Cbz-L-4-fluorophenylalanine chloromethyl ketone; (S)-1-(((Benzyloxy)carbonyl)amino)-3-(4-fluorophenyl)-1-oxopropan-2-yl chloromethyl ketone
EINECS	Contact for details

Quality Control

Our Z-L-p-Fluoro-Phe-Chloromethylketone is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and specific tests for residual solvents and moisture. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.