Description

2-Chloro-1-Methylpyridinium is a versatile and highly reactive organic salt, primarily utilized as a powerful coupling agent in peptide synthesis and other condensation reactions. Its core value lies in its ability to efficiently activate carboxylic acids, facilitating the formation of amide bonds under mild conditions with minimal racemization. This makes it an indispensable reagent for pharmaceutical R&D, fine chemical synthesis, and academic research laboratories focused on developing novel bioactive compounds and complex molecules.

Application

• Peptide Synthesis: As a key coupling reagent (e.g., Mukaiyama's reagent) for activating carboxyl groups in solid-phase and solution-phase peptide synthesis.
• Pharmaceutical Intermediates: For the synthesis of complex drug molecules, including antibiotics and enzyme inhibitors, requiring high-purity amide bond formation.
• Fine Chemical Production: Used in the manufacture of specialty chemicals, agrochemicals, and advanced materials where precise molecular assembly is critical.
• Bioconjugation: Facilitating the linkage of proteins, peptides, or other biomolecules with labels, drugs, or solid supports in biotech applications.
• Academic & Research: A fundamental tool in organic chemistry laboratories for studying reaction mechanisms and developing new synthetic methodologies.
• Esterification & Amidation: Employed as a condensing agent for the preparation of esters and amides from carboxylic acids and alcohols or amines.

Basic Information

Product Name	2-Chloro-1-Methylpyridinium
CAS No.	45528-84-5
Molecular Formula	C7H9ClN+
Molecular Weight	142.60 g/mol
Synonyms	1-Methyl-2-chloropyridinium; 2-Chloro-1-methylpyridinium iodide precursor; Mukaiyama's Reagent; CMPI; 2-Chloro-N-methylpyridinium; N-Methyl-2-chloropyridinium; Chloro-1-methylpyridinium
EINECS	Contact for details

Quality Control

Our 2-Chloro-1-Methylpyridinium is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. Use appropriate precautions to minimize exposure to air and moisture during handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.