Description

H-Leu-Allyl Ester p-Tosylate is a protected amino acid derivative, specifically the allyl ester of H-Leucine with a p-toluenesulfonyl protecting group. This compound is a crucial building block in peptide synthesis, offering a strategic combination of a base-labile allyl ester and an acid-stable tosyl group for orthogonal deprotection strategies. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key intermediate for the controlled incorporation of leucine residues using Fmoc/t-Bu or Boc/Bzl strategies.
• Solution-Phase Peptide Chemistry: Enables segment condensation and convergent synthesis of complex peptide sequences.
• Orthogonal Protection Strategy: The allyl ester group allows for selective deprotection in the presence of other acid- or base-sensitive protecting groups.
• Pharmaceutical Intermediate: Serves as a precursor in the synthesis of peptide-based therapeutics and diagnostic agents.
• Bioconjugation and Labeling: Used to introduce leucine moieties into biomolecules or probes under mild conditions.
• Academic and Industrial R&D: Fundamental research tool for studying peptide structure-activity relationships (SAR) and developing new synthetic methodologies.

Basic Information

Product Name	H-Leu-Allyl Ester p-Tosylate
CAS No.	45012-62-2
Molecular Formula	C₁₇H₂₅NO₅S
Molecular Weight	355.45 g/mol
Synonyms	L-Leucine, N-[(phenylmethoxy)carbonyl]-, allyl ester; N-Cbz-L-Leucine Allyl Ester; Z-Leu-OAll; CBZ-Leu-OAllyl; N-Carbobenzoxy-L-leucine allyl ester; Benzyl N-[(2S)-1-allyloxy-4-methyl-1-oxopentan-2-yl]carbamate; (S)-Allyl 2-(((benzyloxy)carbonyl)amino)-4-methylpentanoate
EINECS	Contact for details

Quality Control

Our H-Leu-Allyl Ester p-Tosylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, which includes data from chiral HPLC, NMR, and mass spectrometry to confirm high chemical and enantiomeric purity suitable for sensitive synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.