Description

2-Methylthioadenosine Triphosphate Tetrasodium is a chemically modified nucleotide analog of adenosine triphosphate (ATP) where a methylthio group replaces a hydroxyl group, presented as a tetrasodium salt for enhanced solubility. This modification is critical for its role as a potent and selective inhibitor of certain ATP-dependent enzymes, making it a valuable tool for probing biochemical pathways. It is primarily utilized by researchers and developers in pharmaceutical discovery, enzymology, and molecular biology for studying purinergic signaling, kinase activity, and nucleotide metabolism.

Application

• Biochemical Research: Used as a substrate analog or competitive inhibitor in enzymatic assays to study ATP-binding sites and enzyme kinetics.
• Pharmaceutical Development: Serves as a key intermediate or reference standard in the discovery of novel therapeutics targeting purinergic receptors and kinases.
• Enzymology Studies: Essential for investigating the mechanism of action of methylthioadenosine phosphorylase and other sulfur-containing nucleotide metabolizing enzymes.
• Signal Transduction Research: Applied in cellular studies to modulate and understand intracellular signaling cascades dependent on ATP analogs.
• Diagnostic Reagent Manufacturing: Potential use in formulating specialized reagents for diagnostic kits targeting specific enzymatic activities.

Basic Information

Product Name	2-Methylthioadenosine Triphosphate Tetrasodium
CAS No.	43170-89-4
Molecular Formula	C11H14N5O12P3S • 4Na
Molecular Weight	Contact for details
Synonyms	2-Methylthio-ATP Tetrasodium Salt; 2-Methylthioadenosine-5'-triphosphate Tetrasodium; 2-MeS-ATP Tetrasodium; 2-(Methylthio)adenosine 5'-(tetrahydrogen triphosphate) tetrasodium salt; Adenosine, 2-(methylthio)-, 5'-(tetrahydrogen triphosphate), tetrasodium salt; MS-ATP Tetrasodium
EINECS	Contact for details

Quality Control

Our 2-Methylthioadenosine Triphosphate Tetrasodium is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Quality is verified through advanced analytical techniques including HPLC and NMR. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
pH (1% Solution)	6.0 - 8.0
Endotoxin (LAL)	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.