Description

n-Octyl-β-D-thiogalactopyranoside (CAS NO 42891-16-7) is a high-purity, non-ionic detergent widely recognized for its efficacy in solubilizing membrane proteins while preserving their native structure and function. Its critical value lies in its ability to effectively extract and stabilize integral membrane proteins for downstream biochemical and structural analysis without causing denaturation. This makes it an indispensable reagent for researchers and manufacturers in structural biology, pharmaceutical development, and biotechnology, where maintaining protein integrity is paramount.

Application

• Membrane Protein Solubilization: Primary application for extracting functional integral membrane proteins from cellular membranes for purification and study.
• Structural Biology: Essential for preparing stable protein samples for techniques like X-ray crystallography, cryo-electron microscopy (cryo-EM), and NMR spectroscopy.
• Biochemical Assays: Used to maintain protein solubility and activity in enzyme kinetics studies, ligand-binding assays, and other in vitro analyses.
• Pharmaceutical Research: Facilitates the study of membrane-bound drug targets, such as G-protein-coupled receptors (GPCRs) and ion channels.
• Vaccine Development: Can be employed in the extraction and formulation of membrane protein antigens.
• Diagnostic Kit Manufacturing: Used as a stabilizing agent in diagnostic assays that rely on membrane-bound biomarkers.

Basic Information

Product Name	n-Octyl-β-D-thiogalactopyranoside
CAS No.	42891-16-7
Molecular Formula	C14H28O5S
Molecular Weight	308.44 g/mol
Synonyms	Octyl-β-D-thiogalactoside; OTG; n-Octyl 1-Thio-β-D-galactopyranoside; n-Octylthiogalactoside; Octylthiogalactopyranoside; 1-Thio-β-D-galactopyranoside octyl; Thiogalactoside, octyl-β-D-; β-D-Octylthiogalactopyranoside
EINECS	255-991-5

Quality Control

Our n-Octyl-β-D-thiogalactopyranoside is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and identity confirmation, to ensure it meets the high standards required for sensitive research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and specific impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. The product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Melting Point	Contact for details
Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.