Description

Hexaethylene Glycol Di(p-Toluenesulfonate) is a high-purity, bifunctional chemical intermediate primarily used as a versatile linker and spacer in advanced organic synthesis. This compound matters for its ability to introduce hydrophilic polyethylene glycol (PEG) chains terminated with reactive tosylate groups, enabling precise molecular construction. It is essential for researchers and manufacturers in the pharmaceutical, bioconjugation, and materials science sectors who require reliable, high-quality building blocks for creating complex molecules, polymers, and functionalized surfaces.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of prodrugs, antibody-drug conjugates (ADCs), and targeted therapeutic agents.
• PEGylation Reagent: Used to introduce hydrophilic PEG spacers onto molecules, peptides, or surfaces to improve solubility, reduce immunogenicity, and prolong circulation time.
• Polymer Chemistry: Acts as a difunctional monomer or cross-linking agent for creating specialized polyethers, hydrogels, and functional polymers.
• Bioconjugation: Facilitates the covalent attachment of dyes, tags, or other molecules to biomolecules like proteins and oligonucleotides.
• Surface Functionalization: Used to modify nanoparticles, chips, or other materials with reactive tosylate groups for further chemical grafting.
• Chemical Research: A valuable tool in organic synthesis for constructing complex molecular architectures requiring defined PEG linkers.

Basic Information

Product Name	Hexaethylene Glycol Di(p-Toluenesulfonate)
CAS No.	42749-27-9
Molecular Formula	C26H38O11S2
Molecular Weight	590.70 g/mol
Synonyms	Hexaethylene glycol ditosylate; PEG6 ditosylate; 1,11-Bis(tosyloxy)-3,6,9-trioxaundecane; Diethylene glycol hexaethylene glycol ditosylate; 2,2'-[1,2-Ethanediylbis(oxy)]bisethanol ditosylate derivative; 3,6,9,12,15,18-Hexaoxaeicosane-1,20-diyl bis(4-methylbenzenesulfonate); 1,11-Ditosyl-3,6,9-trioxaundecane; Bis[2-[2-[2-[2-[2-(p-toluenesulfonyloxy)ethoxy]ethoxy]ethoxy]ethoxy]ethyl] p-toluenesulfonate
EINECS	Contact for details

Quality Control

Our Hexaethylene Glycol Di(p-Toluenesulfonate) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.