Description

Estradiol-2,3-o-Quinone is a specific oxidative metabolite of the endogenous hormone estradiol, representing a key intermediate in estrogen metabolism research. This compound is of significant interest for studying the mechanisms of estrogen-mediated carcinogenesis and oxidative stress pathways. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and academic sectors focused on endocrinology, oncology, and toxicology.

Application

• Biochemical Research: Critical reference standard and intermediate for investigating estrogen metabolism, particularly the formation of reactive catechol estrogen quinones.
• Toxicology Studies: Used in studies examining the genotoxic and cytotoxic effects associated with estrogen oxidation and DNA adduct formation.
• Pharmaceutical Development: Serves as a key metabolite in the development and validation of analytical methods (e.g., LC-MS/MS) for steroid hormone profiling.
• Cancer Research: Employed in mechanistic studies to understand the role of estrogen metabolites in hormone-dependent cancers, such as breast and endometrial cancer.
• Enzymology: Substrate for studying the activity of enzymes like cytochrome P450s and peroxidases involved in estrogen biotransformation.
• Standards and Calibration: High-purity material for use as a certified reference material in analytical laboratories.

Basic Information

Product Name	Estradiol-2,3-o-Quinone
CAS No.	42261-16-5
Molecular Formula	C18H20O3
Molecular Weight	284.35 g/mol
Synonyms	2,3-Dihydroxyestra-1,3,5(10)-trien-17-one; Estra-1,3,5(10)-triene-2,3,17-trione; 2,3-Quinone of Estradiol; E2-2,3-Q; Estradiol quinone; 17-Oxoestra-1,3,5(10)-triene-2,3-diol
EINECS	Contact for details

Quality Control

Our Estradiol-2,3-o-Quinone is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical characterization, including purity assay and identity confirmation. A Certificate of Analysis (COA) detailing specific results for the relevant batch is provided with every shipment, ensuring full traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Solubility	Soluble in DMSO, methanol; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.