Description

N,N,n-Trimethylglycine-n-Hydroxysuccinimide Ester, Bromide is a high-purity, reactive ester derivative of betaine, primarily used as a key intermediate in bioconjugation and peptide synthesis. This compound is critical for introducing a permanent positive charge or a hydrophilic quaternary ammonium group into target molecules, enhancing solubility and modifying biological activity. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic reagent sectors who require reliable, high-quality building blocks for advanced drug development and biochemical labeling.

Application

• Bioconjugation Reagent: For the covalent attachment of ligands, dyes, or drugs to proteins, antibodies, and other biomolecules.
• Peptide Modification: Used to introduce a permanent, positively charged trimethylammonium group onto peptides to alter their physicochemical properties and stability.
• Crosslinking Agent: In the synthesis of affinity chromatography media and solid supports for protein purification.
• Pharmaceutical Intermediate: Serves as a key synthon in the development of prodrugs and targeted therapeutic agents.
• Surface Functionalization: For modifying nanoparticles, polymers, and diagnostic chips to create cationic or hydrophilic surfaces.
• Biomaterial Synthesis: Incorporation into hydrogels and polymeric scaffolds to impart positive charge for cell adhesion studies.

Basic Information

Product Name	N,N,n-Trimethylglycine-n-Hydroxysuccinimide Ester, Bromide
CAS No.	42014-55-1
Molecular Formula	C11H19BrN2O5
Molecular Weight	339.19 g/mol
Synonyms	Betaine NHS Ester Bromide; (Carboxymethyl)trimethylammonium N-hydroxysuccinimide ester bromide; Trimethylglycine NHS ester bromide; N,N,N-Trimethylglycine N-hydroxysuccinimide ester bromide; (3-Carboxypropyl)trimethylammonium N-hydroxysuccinimide ester bromide; TMG-NHS Bromide; Succinimidyl (3-carboxypropyl)trimethylammonium bromide; Glycine betaine NHS ester bromide
EINECS	Contact for details

Quality Control

Our N,N,n-Trimethylglycine-n-Hydroxysuccinimide Ester, Bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.