Description

(20α)-17-Oxoyohimban-16α-Carboxylic Acid Methyl Ester CAS NO 41904-77-2 is a high-purity, specialized indole alkaloid derivative of significant interest in advanced organic synthesis. This compound serves as a critical chiral building block and synthetic intermediate for the development of complex pharmacologically active molecules. It is primarily required by research institutions and pharmaceutical development companies engaged in the synthesis of novel therapeutic agents, particularly within the fields of central nervous system (CNS) and cardiovascular research.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the multi-step synthesis of complex alkaloids and potential drug candidates.
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies and the design of new bioactive molecules.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Asymmetric Synthesis: Utilized in stereoselective synthesis due to its defined chiral centers, enabling the construction of enantiomerically pure compounds.
• Biochemical Research: Employed in studies investigating alkaloid biosynthesis pathways and enzyme interactions.
• Academic & Contract Research: Essential for chemical research in universities and CROs (Contract Research Organizations) focusing on natural product chemistry and synthetic methodology.

Basic Information

Product Name	(20α)-17-Oxoyohimban-16α-Carboxylic Acid Methyl Ester
CAS No.	41904-77-2
Molecular Formula	C21H24N2O3
Molecular Weight	352.43 g/mol
Synonyms	Methyl (20α)-17-oxoyohimban-16α-carboxylate; 16α-Carbomethoxy-17-oxoyohimban; 17-Oxo-yohimban-16α-carboxylic acid methyl ester; Yohimban-16α-carboxylic acid, 17-oxo-, methyl ester, (20α)-; Methyl 17-oxoyohimban-16α-carboxylate; 16α-Methoxycarbonyl-17-oxoyohimban
EINECS	Contact for details

Quality Control

Our (20α)-17-Oxoyohimban-16α-Carboxylic Acid Methyl Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and spectroscopic identification (NMR, IR, MS) to ensure structural integrity and high chemical purity. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.