Description

Phorbol 13,20-Diacetate is a specific, high-purity derivative of the phorbol diterpene family, recognized for its role as a key biochemical tool in life science research. This compound is critical for studying protein kinase C (PKC) signaling pathways, cellular proliferation, and tumor promotion mechanisms. It is primarily utilized by researchers and developers in pharmaceutical R&D, academic institutions, and biotechnology companies focused on oncology, toxicology, and signal transduction studies.

Application

• Biochemical Research: As a potent activator of protein kinase C (PKC) isoforms for investigating signal transduction pathways.
• Oncology Studies: Used as a tumor-promoting agent in experimental models to study carcinogenesis and tumor progression mechanisms.
• Pharmacology & Toxicology: Employed in assays to evaluate the efficacy and mechanisms of potential PKC inhibitors and chemopreventive agents.
• Cell Biology: A tool for studying effects on cell differentiation, apoptosis, and inflammatory responses in various cell lines.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	Phorbol 13,20-Diacetate
CAS No.	41621-85-6
Molecular Formula	C28H36O9
Molecular Weight	516.58 g/mol
Synonyms	13,20-Di-O-acetylphorbol; 12-O-Tetradecanoylphorbol-13-acetate related compound; Phorbol 13-acetate 20-acetate; 4,9,12-beta,13,20-Pentahydroxy-1,6-tigliadien-3-one 13,20-diacetate; TPA derivative; NSC 268508; 12-O-Tetradecanoylphorbol-13-acetate Impurity
EINECS	Contact for details

Quality Control

Our Phorbol 13,20-Diacetate is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to relevant guidelines for research-grade biochemicals to support the integrity of your scientific work.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at -20°C under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solubility	Soluble in DMSO, ethanol, acetone; sparingly soluble in water
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.