Description

Bicuculline Methoxide is a potent and selective competitive antagonist of the GABAA receptor, a key target in neuropharmacological research. This high-purity compound is essential for studying inhibitory neurotransmission, neuronal excitability, and the mechanisms underlying various neurological conditions. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic manufacturers focused on neuroscience and drug discovery.

Application

• Neuroscience Research: A critical tool for investigating GABAergic synaptic transmission, neuronal network activity, and receptor pharmacology in vitro and in vivo.
• Pharmacological Studies: Used to characterize and validate the function of GABAA receptor subtypes in assay development and high-throughput screening.
• Disease Model Research: Employed in experimental models of epilepsy, anxiety, and sleep disorders to understand disease pathophysiology and identify potential therapeutic targets.
• Biochemical Assays: Serves as a reference standard in competitive binding assays and functional studies to determine the potency of novel compounds.
• Academic & Institutional R&D: Fundamental reagent for university laboratories and research institutes conducting basic and applied neurobiological research.

Basic Information

Product Name	Bicuculline Methoxide
CAS No.	41544-46-1
Molecular Formula	C21H19NO6
Molecular Weight	381.38 g/mol
Synonyms	Bicuculline Methochloride; (+)-Bicuculline Methiodide (common misnomer); NSC 224994; (R)-Bicuculline Methochloride; 1(S),9(R)-Bicuculline Methochloride; 6-((5S,6S,8R,9R)-5,8,9,10-Tetrahydro-6,9-methanofuro[2,3-h][1,3]benzodioxol-8-yl)-6H-furo[2,3-h]furo[3,2-c]pyridine-2,8-diol, Methyl Derivative
EINECS	Contact for details

Quality Control

Our Bicuculline Methoxide is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is subjected to comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.