Description

(R)-Glycerol 1-(p-Toluenesulfonate) is a high-purity chiral building block and synthetic intermediate of significant value in asymmetric synthesis. This compound matters because it provides a protected, enantiomerically pure glycerol derivative, enabling the stereoselective construction of complex molecules in pharmaceutical and fine chemical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of active pharmaceutical ingredients (APIs), natural products, and advanced materials.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of enantiomerically pure β-blockers, antiviral agents, and other bioactive molecules.
• Asymmetric Synthesis: Used in the preparation of chiral glycerol derivatives, phospholipids, and glyceryl ethers for research and development.
• Protecting Group Chemistry: The p-toluenesulfonate (tosylate) group serves as an excellent leaving group for nucleophilic substitution reactions to introduce functionalized side chains.
• Glycidol Derivative Synthesis: A precursor in the synthesis of enantiopure glycidol and its derivatives, which are valuable epoxide intermediates.
• Lipid and Surfactant Research: Building block for the study and production of enantiomerically pure lipids, glycolipids, and non-ionic surfactants.
• Material Science: Used in the research of chiral polymers and liquid crystals where specific stereochemistry is required for functional properties.

Basic Information

Product Name	(R)-Glycerol 1-(p-Toluenesulfonate)
CAS No.	41274-09-3
Molecular Formula	C10H14O5S
Molecular Weight	246.28 g/mol
Synonyms	(R)-1-O-(p-Tolylsulfonyl)glycerol; (R)-1-Tosylglycerol; (R)-3-Hydroxy-2-hydroxypropyl 4-methylbenzenesulfonate; (R)-Glyceryl 1-tosylate; (R)-1-O-Tosyl-sn-glycerol; (R)-2,3-Dihydroxypropyl 4-methylbenzenesulfonate; (R)-Glycerol α-tosylate; D-Glycerol 1-(p-toluenesulfonate)
EINECS	Contact for details

Quality Control

Our (R)-Glycerol 1-(p-Toluenesulfonate) is manufactured under strict quality control protocols to ensure high enantiomeric purity and chemical consistency, suitable for demanding synthetic applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles. We adhere to cGMP principles where applicable to support our clients in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.