Description

4-Azidoestradiol is a synthetic, azide-functionalized derivative of the natural hormone estradiol. This compound serves as a critical photoaffinity labeling agent and molecular probe in biochemical research, enabling the study of estrogen receptor interactions and binding sites. It is primarily utilized by research institutions and pharmaceutical development laboratories engaged in endocrinology, cancer research, and drug discovery programs.

Application

• Photoaffinity Labeling: Acts as a covalent cross-linking probe for mapping estrogen receptor (ER) ligand-binding domains and identifying protein targets.
• Biochemical Research: Used as a tool compound to investigate the mechanisms of estrogen action, receptor activation, and downstream signaling pathways.
• Drug Discovery: Serves as a key intermediate or probe in the development and screening of novel Selective Estrogen Receptor Modulators (SERMs) and other endocrine therapies.
• Molecular Imaging: Potential use in developing labeled analogs for imaging studies, though specific applications require further conjugation.
• Academic & Pharmaceutical R&D: Essential for basic and applied research in universities, contract research organizations (CROs), and biopharma companies focusing on hormone-related diseases.

Basic Information

Product Name	4-Azidoestradiol
CAS No.	41164-45-8
Molecular Formula	C18H23N3O2
Molecular Weight	313.40 g/mol
Synonyms	Estra-1,3,5(10)-triene-3,17β-diol, 4-azido-; 4-Azido-17β-estradiol; 4-Azidoestra-1,3,5(10)-triene-3,17β-diol; 17β-Estradiol 4-azide; Azidoestradiol
EINECS	Contact for details

Quality Control

Our 4-Azidoestradiol is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed immediately after use to minimize exposure to air and light.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Loss on Drying	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.