Description

Ac-Glu-Pna CAS NO 41149-11-5 is a specialized protected amino acid derivative, specifically N-Acetyl-L-glutamic acid p-nitroanilide. This high-purity biochemical building block is critical for research and development in advanced life sciences. It serves as a key substrate and synthetic intermediate for pharmaceutical and proteomic applications. This compound is essential for researchers and manufacturers in peptide synthesis, enzyme studies, and diagnostic reagent development.

Application

• Enzyme Substrate: Used as a chromogenic substrate for the study and assay of proteolytic enzymes, particularly glutamyl endopeptidases.
• Peptide Synthesis Intermediate: Serves as a protected glutamic acid derivative in solid-phase and solution-phase peptide synthesis for research and pharmaceutical development.
• Biochemical Research: Employed in mechanistic studies of enzyme kinetics, specificity, and inhibition within academic and industrial R&D laboratories.
• Diagnostic Reagent Manufacturing: Acts as a key raw material in formulating specialized diagnostic kits and assays for clinical and research use.
• Proteomics & Cell Biology: Utilized in studies of protein-protein interactions and cellular signaling pathways that involve glutamic acid-specific processing.

Basic Information

Product Name	Ac-Glu-Pna
CAS No.	41149-11-5
Molecular Formula	C13H15N3O6
Molecular Weight	309.28 g/mol
Synonyms	N-Acetyl-L-glutamic acid 4-nitroanilide; N-Acetyl-L-glutamic acid p-nitroanilide; Ac-Glu-pNA; L-Glutamic acid, N-acetyl-, 4-nitroanilide; N-Acetylglutamic acid p-nitroanilide; N-ACETYL-L-GLUTAMIC ACID P-NITROANILIDE; Substrate for Glu-specific proteases; Ac-Glu-4-nitroanilide
EINECS	Contact for details

Quality Control

Our Ac-Glu-Pna is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, identity confirmation by IR and NMR spectroscopy, and precise determination of optical rotation. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research-grade specifications and consistent batch-to-batch performance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.