Description

Asialo Gm2 CAS NO 41106-94-9 is a high-purity ganglioside derivative, specifically the asialo form of GM2, which is a critical intermediate and reference standard in glycolipid research. This compound is essential for studying cell membrane structure, signal transduction pathways, and the biochemical mechanisms underlying various neurological and lysosomal storage disorders. It is primarily utilized by research institutions, diagnostic kit manufacturers, and pharmaceutical companies engaged in neuroscience, immunology, and the development of therapeutic agents.

Application

• Biochemical Research: Serves as a key reference standard and substrate for enzyme activity assays, particularly for hexosaminidase A, in studies related to Tay-Sachs disease.
• Diagnostic Development: Used in the formulation of diagnostic kits and reagents for the detection of genetic disorders and autoimmune diseases involving ganglioside antibodies.
• Neuroscience Studies: Employed in lipid raft research to investigate its role in neuronal cell adhesion, recognition, and signal transduction processes.
• Pharmaceutical Intermediates: Acts as a crucial starting material or intermediate in the synthesis of more complex glycoconjugates for potential therapeutic applications.
• Immunology Research: Utilized to study immune responses, including the generation and specificity of anti-ganglioside antibodies found in certain neuropathies.
• Quality Control: Functions as an analytical standard in HPLC, MS, and TLC for the quality assessment of related biological products and extracts.

Basic Information

Item	Details
Product Name	Asialo Gm2
CAS No.	41106-94-9
Molecular Formula	C56H99N3O20
Molecular Weight	1134.39 g/mol
Synonyms	Asialo-GM2; II3-α-N-Acetylneuraminosyl-GgOse4Cer; GA2; Asialo-Ganglioside GM2; GM2-Asialo; Tay-Sachs Ganglioside GA2; β-D-Galactosyl-N-acetyl-β-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide (asialo form); N-Acetyl-β-D-galactosaminyl-(1→4)-[α-N-acetylneuraminyl-(2→3)]-β-D-galactosyl-(1→4)-β-D-glucosylceramide (asialo)
EINECS	Contact for details

Quality Control

Every batch of Asialo Gm2 is produced and analyzed under strict quality management protocols to ensure identity, purity, and consistency. Our quality control includes comprehensive analytical techniques such as HPLC, mass spectrometry, and NMR for definitive characterization. A Certificate of Analysis (COA) detailing purity, assay results, and impurity profiles is provided with each shipment, supporting compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, consider under an inert atmosphere. Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Solubility	Soluble in chloroform/methanol/water mixtures

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.