Description

Penta(Ethylene Glycol) Di-p-Toluenesulfonate is a high-purity, bifunctional chemical intermediate featuring terminal tosylate groups separated by a flexible pentaethylene glycol spacer. This compound is valued for its role as a versatile linker and building block in advanced organic synthesis, enabling the controlled introduction of hydrophilic chains. It is primarily sought by researchers and manufacturers in the pharmaceutical, polymer, and specialty chemical industries for applications ranging from prodrug development to the creation of functionalized materials and cross-linking agents.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of prodrugs, antibody-drug conjugates (ADCs), and polyethylene glycol (PEG)-ylated therapeutic agents.
• Polymer & Material Science: Serves as a hydrophilic cross-linker or spacer in the production of hydrogels, functionalized surfaces, and smart polymers.
• Bioconjugation Chemistry: Used to attach bioactive molecules (e.g., peptides, dyes, targeting ligands) to nanoparticles, proteins, or other macromolecules via its reactive tosylate groups.
• Organic Synthesis: Acts as a versatile alkylating agent for introducing polyether chains into molecular frameworks under controlled conditions.
• Ligand & Catalyst Design: Employed in the preparation of chelating ligands or supported catalysts where a flexible, water-soluble tether is required.
• Surface Modification: Facilitates the functionalization of glass, silicon, or metal oxides with poly(ethylene glycol) layers to create non-fouling or specific binding surfaces.

Basic Information

Product Name	Penta(Ethylene Glycol) Di-p-Toluenesulfonate
CAS No.	41024-91-3
Molecular Formula	C24H34O10S2
Molecular Weight	546.65 g/mol
Synonyms	PEG5 ditosylate; 3,6,9,12,15-Pentaoxaheptadecane-1,17-diyl bis(4-methylbenzenesulfonate); 1,17-Bis(tosyloxy)-3,6,9,12,15-pentaoxaheptadecane; Diethylene glycol ditosylate, pentamer; p-Toluenesulfonic acid pentaethylene glycol diester; Pentaethylene glycol ditosylate; TsO-PEG5-OTs; 1,17-Ditosyl-3,6,9,12,15-pentaoxaheptadecane
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and industrial use. Each batch is characterized to confirm identity, purity, and consistency. Certificates of Analysis (COA) are available upon request, detailing key parameters such as assay, impurity profile, and moisture content to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.