Description

Methyllycaconitine Perchlorate is a high-purity, potent alkaloid derivative used extensively in neuroscience and pharmacological research. This compound serves as a highly selective and competitive antagonist for the α7 subtype of nicotinic acetylcholine receptors (nAChRs). It is an essential tool for researchers and pharmaceutical developers in the life sciences sector, enabling critical studies on receptor function, neurological pathways, and potential therapeutic targets.

Application

• Neuroscience Research: A key pharmacological tool for selectively blocking α7 nicotinic acetylcholine receptors in vitro and in vivo studies.
• Drug Discovery & Development: Used in high-throughput screening (HTS) assays to identify and characterize novel compounds targeting nAChR pathways.
• Biochemical Studies: Employed in receptor binding assays and functional studies to understand synaptic transmission and neuro-modulation.
• Toxicology & Safety Pharmacology: Acts as a reference standard in studies investigating the effects of neuroactive compounds and plant-derived toxins.
• Academic & Institutional Research: Fundamental for university and research institute projects focused on cognitive function, neuropathic pain, and neurodegenerative conditions.
• Diagnostic Reagent Manufacturing: Potential use in the development of specialized diagnostic kits and research reagents for neurological disorders.

Basic Information

Product Name	Methyllycaconitine Perchlorate
CAS No.	40819-78-1
Molecular Formula	C37H50ClN O11 • HClO4
Molecular Weight	Contact for details
Synonyms	MLA Perchlorate; Methyllycaconitine Perchlorate Salt; 16β-Methyllycaconitine Perchlorate; (1α,14α,16β)-20-Ethyl-1,14,16-trimethoxyaconitane-7,8-diol Perchlorate; Lycoctonine, 16-methyl-, perchlorate; α7 nAChR Antagonist (MLA); NSC 119875 (Perchlorate)
EINECS	Contact for details

Quality Control

Our Methyllycaconitine Perchlorate is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS). A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with our stringent internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This material is light-sensitive (store away from light) and should be handled with appropriate personal protective equipment in a well-ventilated laboratory setting. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.