Description

n-(Guanosin-8-Yl)-2-Aminofluorene is a structurally defined, high-purity chemical adduct formed between the mutagen 2-aminofluorene and the nucleoside guanosine. This compound is of critical importance as a reference standard and biomarker in biochemical and toxicological research. It is primarily required by research institutions, diagnostic laboratories, and pharmaceutical companies engaged in studying DNA damage, carcinogenesis, and metabolic pathways.

Application

• Biomarker Standard: Used as a precise analytical standard for the quantification of DNA adducts in biological samples via techniques like 32P-postlabeling, HPLC-MS, or immunoassays.
• Toxicology Research: Serves as a critical tool in mechanistic studies of chemical carcinogenesis, specifically for understanding the metabolic activation and DNA-binding profiles of aromatic amines.
• Method Development & Validation: Essential for developing and validating new, sensitive analytical methods for detecting and characterizing DNA damage.
• Reference Material: Acts as a certified reference material (CRM) in quality control for laboratories monitoring exposure to genotoxic compounds.
• Educational & Forensic Analysis: Used in advanced academic settings for teaching molecular toxicology and in forensic science for investigating exposure to specific mutagens.

Basic Information

Product Name	n-(Guanosin-8-Yl)-2-Aminofluorene
CAS No.	40762-21-8
Molecular Formula	C24H23N7O5
Molecular Weight	489.48 g/mol
Synonyms	N-(Guanosin-8-yl)-2-aminofluorene; 8-(2-Fluorenylamino)guanosine; AF-Guo; dG-C8-AF; Guanine-8-yl-2-aminofluorene adduct; 2-Aminofluorene-guanosine adduct; N-(Deoxyguanosin-8-yl)-2-aminofluorene (related); C8-Guanine-2-aminofluorene adduct
EINECS	Contact for details

Quality Control

Every batch of n-(Guanosin-8-Yl)-2-Aminofluorene is produced and analyzed under strict quality protocols to ensure identity, purity, and stability. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, identification, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under inert atmosphere at -20°C.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.