Description

Linoleoyl-Coenzyme A is a crucial biochemical intermediate, specifically an activated fatty acyl thioester derivative of linoleic acid. This compound is essential for research into lipid metabolism, serving as a key substrate for enzymes like desaturases and elongases. It is primarily utilized by biochemists and pharmaceutical researchers studying fatty acid biosynthesis, β-oxidation pathways, and metabolic disorders.

Application

• Biochemical Research: Critical substrate for studying fatty acid desaturation (e.g., δ6-desaturase activity) and elongation processes in vitro.
• Enzyme Kinetics & Inhibition Studies: Used to assay the activity and characterize the specificity of acyl-CoA synthetases, thioesterases, and transferases.
• Metabolic Pathway Analysis: Investigation of polyunsaturated fatty acid (PUFA) biosynthesis and related disorders in cell culture and model systems.
• Pharmaceutical Development: Tool compound for screening and developing inhibitors targeting lipid metabolism enzymes for therapeutic applications.
• Nutritional Science: Research into the metabolic fate of dietary linoleic acid and its conversion to longer-chain PUFAs like arachidonic acid.
• Diagnostic Reagent Manufacturing: Potential component in enzymatic assay kits for clinical diagnostics of metabolic conditions.

Basic Information

Product Name	Linoleoyl-Coenzyme A
CAS No.	40757-80-0
Molecular Formula	C39H66N7O17P3S
Molecular Weight	1049.94 g/mol
Synonyms	Linoleoyl-CoA; (9Z,12Z)-Octadecadienoyl-CoA; Coenzyme A, S-(9Z,12Z)-1-oxooctadeca-9,12-dien-1-yl ester; Linoleic acid CoA thioester; cis,cis-9,12-Octadecadienoyl coenzyme A; 9,12-Linoleoyl coenzyme A; (all-Z)-9,12-Octadecadienoyl-CoA
EINECS	Contact for details

Quality Control

Our Linoleoyl-Coenzyme A is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing including HPLC for purity and identity confirmation via mass spectrometry. A detailed Certificate of Analysis (COA) is provided, documenting assay, purity, and stability data.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and hydrolysis. The product is hygroscopic and moisture-sensitive; allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or lyophilized solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Enzymatic/UV)	≥ 90% (of theoretical CoA content)
Water Content (KF)	≤ 5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.