Description

4-(n-Maleimido)Benzyltrimethylammonium is a specialized, high-purity chemical reagent featuring a reactive maleimide group linked to a quaternary ammonium moiety. This unique bifunctional structure makes it a critical intermediate for the site-specific conjugation of biomolecules, enabling the development of advanced diagnostic and therapeutic agents. It is primarily utilized by researchers and manufacturers in the pharmaceutical, bioconjugation, and life science sectors for creating stable, targeted molecular constructs.

Application

• Key intermediate in the synthesis of antibody-drug conjugates (ADCs) and other targeted biopharmaceuticals.
• Cross-linking reagent for the covalent immobilization of proteins, peptides, or enzymes onto solid supports or other polymers.
• Tool compound in biochemical research for labeling thiol-containing biomolecules via Michael addition.
• Modification agent for introducing permanent positive charges (quaternary ammonium groups) into polymers or surfaces.
• Component in the development of diagnostic assays and biosensors requiring stable biomolecule attachment.
• Building block for advanced material science applications, such as functionalized hydrogels or smart coatings.

Basic Information

Product Name	4-(n-Maleimido)Benzyltrimethylammonium
CAS No.	40748-21-8
Molecular Formula	C15H19N3O2+ • X-
Molecular Weight	273.33 g/mol (Cation)
Synonyms	N-(4-Trimethylammoniobenzyl)maleimide; 4-(Maleimidomethyl)benzyltrimethylammonium; Maleimido-PEG1-TMAB; TMA-Maleimide; 4-(N-Maleimidomethyl)benzyltrimethylammonium salt; Benzyltrimethylammonium 4-maleimide; p-Maleimidobenzyltrimethylammonium
EINECS	Contact for details

Quality Control

Every batch of 4-(n-Maleimido)Benzyltrimethylammonium is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as assay (HPLC), impurity profile, and appearance. Our quality commitment supports applications requiring high-purity biochemical intermediates, from research to GMP-grade manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water, DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.