Description

(S)-(+)-1-Phenyl-1,2-Ethanediol 2-Tosylate is a high-purity chiral building block and synthetic intermediate of significant importance in asymmetric organic synthesis. Its value lies in the activated tosylate group, which serves as an excellent leaving group for nucleophilic substitution reactions, enabling the stereoselective construction of complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries developing active pharmaceutical ingredients (APIs), chiral ligands, and advanced materials.

Application

• Chiral Intermediate in Pharmaceutical Synthesis: A key precursor for the production of enantiomerically pure drugs, particularly in the synthesis of β-blockers, antidepressants, and other bioactive molecules.
• Asymmetric Catalyst and Ligand Preparation: Used in the development and synthesis of novel chiral catalysts and auxiliaries for stereocontrolled chemical transformations.
• Fine Chemical and Specialty Material Production: Serves as a building block for advanced polymers, liquid crystals, and other high-value specialty chemicals requiring specific stereochemistry.
• Academic and R&D Laboratories: A valuable reagent for methodological studies in organic chemistry, including investigations into stereoselective reactions and mechanism studies.

Basic Information

Product Name	(S)-(+)-1-Phenyl-1,2-Ethanediol 2-Tosylate
CAS No.	40435-14-1
Molecular Formula	C15H16O4S
Molecular Weight	292.35 g/mol
Synonyms	(S)-(+)-1,2-Dihydroxy-1-phenylethyl 4-methylbenzenesulfonate; (S)-1-Phenyl-2-(p-toluenesulfonyloxy)ethanol; (S)-Styrene Glycol Tosylate; (S)-1-Phenylethane-1,2-diol 2-tosylate; (S)-1,2-Dihydroxy-1-phenylethyl tosylate; (S)-Phenylglycidyl tosylate (related); (S)-Hydrobenzoin tosylate; (S)-1-Phenyl-1,2-ethanediol mono-p-toluenesulfonate
EINECS	Contact for details

Quality Control

Our (S)-(+)-1-Phenyl-1,2-Ethanediol 2-Tosylate is produced under strict quality management protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing critical parameters such as chiral purity (enantiomeric excess), chemical purity, and identity confirmation. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.