Description

Ac-Arg-Pna Hcl is a chemically modified arginine derivative, specifically an acetylated arginine para-nitroanilide hydrochloride salt. This compound serves as a critical chromogenic substrate for enzymatic assays, enabling precise measurement of protease activity. It is primarily utilized by pharmaceutical researchers, diagnostic kit manufacturers, and biochemical laboratories for drug discovery, quality control, and fundamental proteolysis studies.

Application

• Protease Activity Assays: As a chromogenic substrate for trypsin, thrombin, and other serine proteases in kinetic studies.
• Diagnostic Reagent Manufacturing: A key component in the production of test kits for clinical diagnostics and blood coagulation analysis.
• Pharmaceutical R&D: Used in high-throughput screening (HTS) platforms to identify and characterize novel protease inhibitors for therapeutic development.
• Biochemical Research: Employed in enzyme kinetics, mechanism of action studies, and purity assessment of protease preparations.
• Quality Control: Acts as a reference standard for calibrating enzymatic assays in industrial and academic laboratory settings.

Basic Information

Product Name	Ac-Arg-Pna Hcl
CAS No.	40127-26-2
Molecular Formula	C14H21N7O4 • HCl
Molecular Weight	411.83 g/mol
Synonyms	N-α-Acetyl-L-arginine 4-nitroanilide hydrochloride; Acetyl-L-arginine-p-nitroanilide hydrochloride; Ac-Arg-pNA • HCl; L-Arginine, N2-acetyl-, 4-nitroanilide, monohydrochloride; Substrate for trypsin; Chromogenic trypsin substrate; 40127-26-2
EINECS	Contact for details

Quality Control

Our Ac-Arg-Pna Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and specific optical rotation verification. We provide full traceability and Certificates of Analysis (COA) are available for every shipment to ensure compliance with your research and production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.