Description

6-Mercaptopurine Riboside is a purine analog nucleoside derivative, serving as a key intermediate in pharmaceutical research and development. This compound is valued for its role in the synthesis of active metabolites and its application in biochemical studies, particularly in oncology and immunology research. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in the development of chemotherapeutic agents and metabolic pathway investigations.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs) for chemotherapeutic drugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to purine metabolism and nucleotide salvage pathways.
• Oncology Research: Investigated for its potential antimetabolite activity in cell culture and preclinical studies targeting leukemia and autoimmune diseases.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.
• Metabolite Studies: Employed in research to understand the metabolic activation and disposition of related thiopurine drugs.

Basic Information

Product Name	6-Mercaptopurine Riboside
CAS No.	4988-64-1
Molecular Formula	C10H12N4O4S
Molecular Weight	284.29 g/mol
Synonyms	6-Thioinosine; 6-MP Riboside; 6-Thioguanosine (related analog); Thioinosine; 9-β-D-Ribofuranosyl-6-mercaptopurine; 6-MPR; NSC-4911; Mercaptopurine ribonucleoside
EINECS	225-647-9

Quality Control

Our 6-Mercaptopurine Riboside is manufactured under a quality management system and undergoes rigorous analytical testing to ensure high purity and consistency. Standard quality parameters include identification by spectroscopic methods, assay by HPLC, and control of related substances. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with each batch. We can supply material suitable for research and development purposes, with specifications aligned with industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.